Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6411638 | 0.87 | L3MBTL1 (0.57) | L3MBTL1LMNAMAPTEPHX2SMN1; SMN2 | |
| SCHEMBL6409410 | 0.86 | FAAH (0.48) | L3MBTL1LMNASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL6411317 | 0.85 | TP53 (0.41) | MAPTSMN1; SMN2HTTPOLBTNF | |
| SCHEMBL6411508 | 0.85 | L3MBTL1 (0.45) | L3MBTL1LMNAMAPTEPHX2SMN1; SMN2 | |
| SCHEMBL6409449 | 0.78 | CYP2C19 (0.49) | L3MBTL1LMNASMN1; SMN2HTTPOLB | |
| SCHEMBL2400381 | 0.77 | EPHX2 (0.51) | L3MBTL1LMNAMAPTEPHX2SMN1; SMN2 | |
| SCHEMBL2404605 | 0.76 | L3MBTL1 (0.47) | L3MBTL1LMNAMAPTEPHX2SMN1; SMN2 | |
| SCHEMBL2400766 | 0.76 | L3MBTL1 (0.45) | L3MBTL1LMNAMAPTEPHX2SMN1; SMN2 | |
| SCHEMBL6417412 | 0.76 | ATM (0.51) | L3MBTL1MAPTSMN1; SMN2HTTPOLB | |
| SCHEMBL6412249 | 0.76 | JAK2 (0.43) | L3MBTL1SMN1; SMN2HTTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1401841-B1 | SUBSTITUTED 1-OXA-2,8-DIAZA-SPIRO 4,5]DEC-2-ENE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2005-08-24 | — | — | EP | disclosed |