Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.57 |
| ▸ | MC4R | P32245 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 4/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.50 |
| ▸ | DRD1 | P21728 | 2/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | BCL2 | P10415 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420676 | 0.88 | CYP2D6 (0.77) | CYP2D6CHRM2CHRM1MC4RALDH1A1 | |
| SCHEMBL6412443 | 0.83 | MCOLN2 (0.60) | CYP2D6CHRM2CHRM1MC4RTSHR | |
| SCHEMBL7264542 | 0.80 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1MC4RADRA2A | |
| SCHEMBL6706135 | 0.80 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1MC4RADRA2A | |
| SCHEMBL16226061 | 0.80 | CYP2D6 (1.00) | CYP2D6CHRM2CHRM1MC4RADRA2A | |
| SCHEMBL13898896 | 0.79 | KDM4E (0.67) | DRD4HRH3ALDH1A1LMNAKDM4E | |
| SCHEMBL6708152 | 0.78 | CYP2D6 (0.56) | CYP2D6CHRM2CHRM1MC4RDRD4 | |
| SCHEMBL8173437 | 0.78 | KDM4E (0.50) | DRD4ALDH1A1LMNAKDM4EGFER | |
| SCHEMBL8781454 | 0.77 | CHRM2 (0.61) | CYP2D6CHRM2CHRM1MC4RCNR1 | |
| SCHEMBL10725624 | 0.77 | CHRM2 (0.65) | CYP2D6CHRM2CHRM1MC4RTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050239799-A1 | 1-phenyl-4-benzylpiperazines dopamine receptor subtype | NEUROGEN CORPORATION (US) | 2005-10-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239799-A1 | 1-phenyl-4-benzylpiperazines dopamine receptor subtype | DRD2, DRD4, HTR2C | CYP2D6 330/4885CHRM2 80/4885CHRM1 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.