Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6408922 | 0.99 | SIGMAR1 (0.44) | SIGMAR1CCR5OPRD1OPRK1KMT2A | |
| SCHEMBL6416093 | 0.94 | CCR5 (0.49) | SIGMAR1CCR5OPRD1OPRK1KMT2A | |
| Hydrochloric Acid SCHEMBL6417642 | 0.93 | CCR5 (0.49) | SIGMAR1CCR5OPRD1OPRK1KMT2A | |
| SCHEMBL6417585 | 0.92 | SIGMAR1 (0.45) | SIGMAR1CCR5 | |
| Hydrochloric Acid SCHEMBL6409005 | 0.91 | SIGMAR1 (0.45) | SIGMAR1CCR5 | |
| SCHEMBL6410251 | 0.91 | SIGMAR1 (0.43) | SIGMAR1CCR5KMT2AMEN1GAA | |
| SCHEMBL6410012 | 0.91 | CCR5 (0.53) | SIGMAR1CCR5 | |
| SCHEMBL6411114 | 0.90 | SIGMAR1 (0.42) | SIGMAR1CCR5OPRD1OPRK1KMT2A | |
| Hydrochloric Acid SCHEMBL6409468 | 0.90 | SIGMAR1 (0.42) | SIGMAR1CCR5KMT2AMEN1GAA | |
| Hydrochloric Acid SCHEMBL6415132 | 0.90 | CCR5 (0.52) | SIGMAR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA INC (CA) | 2005-04-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | CXCR1, CXCR4, CXCR2 | SIGMAR1 277/4885CCR5 4/4885OPRD1 177/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.