Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL639470 | 0.89 | EPHX1 (0.45) | CYP2C19CYP2D6EPHX1MMP1MMP8 | |
| SCHEMBL642266 | 0.85 | CYP2C19 (0.50) | CYP2C19CYP2D6EPHX1MMP1MMP8 | |
| SCHEMBL8507231 | 0.80 | FNTA (0.39) | MMP1MMP8THRBFNTAFNTB | |
| SCHEMBL432886 | 0.76 | CASP2 (0.46) | EPHX1THRBFNTAFNTBPGGT1B | |
| SCHEMBL2497942 | 0.74 | FNTA (0.35) | THRBFNTAFNTBPGGT1BALDH1A1 | |
| SCHEMBL1053072 | 0.74 | HDAC3 (0.41) | THRBFNTAFNTBPGGT1BALDH1A1 | |
| SCHEMBL18229223 | 0.73 | POLB (0.41) | CYP2C19THRBFNTAFNTBPGGT1B | |
| SCHEMBL18579741 | 0.73 | FAAH (0.46) | MAPTTHRBFNTAFNTBPGGT1B | |
| SCHEMBL2604889 | 0.71 | CYP2D6 (0.52) | CYP2C19CYP2D6EPHX1MMP1MMP8 | |
| SCHEMBL1143033 | 0.69 | FNTA (0.37) | EPHX1THRBFNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090103045-A1 | SILICONE HYDROGELS WITH AMINO SURFACE GROUPS | SALIX PHARMACEUTICALS, INC. | 2009-04-23 | — | — | US | claimed |
| US-8119753-B2 | Silicone hydrogels with amino surface groups | BAUSCH & LOMB INCORPORATED (US) | 2012-02-21 | — | — | US | disclosed |
| US-20090103045-A1 | SILICONE HYDROGELS WITH AMINO SURFACE GROUPS | SALIX PHARMACEUTICALS, INC. | 2009-04-23 | — | — | US | disclosed |