Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 3/20 | 0.31 |
| ▸ | CA1 | P00915 | 3/20 | 0.31 |
| ▸ | CA2 | P00918 | 3/20 | 0.31 |
| ▸ | CA7 | P43166 | 3/20 | 0.31 |
| ▸ | CA9 | Q16790 | 3/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7411501 | 0.91 | ALDH1A1 (0.35) | MAPTTSHRLMNAALDH1A1ESR1 | |
| SCHEMBL7418768 | 0.87 | TSHR (0.38) | CYP1A2CYP3A4TSHRLMNAL3MBTL1 | |
| SCHEMBL6035356 | 0.83 | CYP1A2 (0.42) | FGFR1FLT1FGFR3MAPTMEN1 | |
| SCHEMBL7413745 | 0.71 | ALDH1A1 (0.44) | MAPTCYP1A2CYP3A4TSHRLMNA | |
| SCHEMBL7415710 | 0.69 | TSHR (0.47) | CYP1A2CYP3A4TSHRLMNAL3MBTL1 | |
| SCHEMBL6421365 | 0.65 | NPSR1 (0.38) | FGFR1FGFR3MAPTNPSR1TSHR | |
| SCHEMBL9626490 | 0.57 | ALDH1A1 (0.49) | MAPTMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL7047552 | 0.57 | CYP1A2 (0.38) | MAPTMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL17146906 | 0.57 | TSHR (0.59) | MAPTMEN1KMT2ACYP1A2TSHR | |
| SCHEMBL4625850 | 0.55 | TSHR (0.61) | MAPTMEN1KMT2ACYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1071474-B1 | SUBSTITUTED PORPHYRINS | UNIV DUKE (US) | 2005-11-30 | — | — | EP | disclosed |
| US-6479477-B1 | SUITABLE FOR USE IN MODULATING INTRA- AND EXTRACELLULAR PROCESSES IN WHICH SUPEROXIDE RADICALS, OR OTHER OXIDANTS SUCH AS HYDROGEN PEROXIDE OR PEROXYNITRITE, ARE A PARTICIPANT | DUKE UNIVERSITY | 2002-11-12 | — | — | US | disclosed |
| EP-1071474-A4 | SUBSTITUTED PORPHYRINS | UNIV DUKE (US) | 2002-10-24 | — | — | EP | disclosed |
| EP-1071474-A1 | SUBSTITUTED PORPHYRINS | DUKE UNIVERSITY (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999055388-A9 | SUBSTITUTED PORPHYRINS | UNIV DUKE (US) | 2000-01-27 | — | — | WO | disclosed |
| WO-1999055388-A1 | SUBSTITUTED PORPHYRINS | DUKE UNIVERSITY (US) | 1999-11-04 | — | — | WO | disclosed |