Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA7 | P43166 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7413745 | 0.86 | ALDH1A1 (0.44) | CYP1A2TSHRMAPTESR1LMNA | |
| SCHEMBL7415710 | 0.83 | TSHR (0.47) | CYP1A2TSHRESR1LMNANR1H2 | |
| SCHEMBL6421365 | 0.79 | NPSR1 (0.38) | TSHRMAPTFGFR1FGFR3CA12 | |
| SCHEMBL7411501 | 0.74 | ALDH1A1 (0.35) | TSHRMAPTESR1LMNAALDH1A1 | |
| SCHEMBL7418768 | 0.73 | TSHR (0.38) | CYP1A2TSHRESR1LMNANR1H2 | |
| SCHEMBL6687802 | 0.69 | RARA (0.51) | CYP1A2TSHRMAPTMEN1KMT2A | |
| SCHEMBL6439546 | 0.68 | — | — | |
| SCHEMBL9626490 | 0.66 | ALDH1A1 (0.49) | CYP1A2TSHRMAPTMEN1KMT2A | |
| SCHEMBL4921789 | 0.63 | CYP1A2 (0.46) | CYP1A2TSHRMEN1KMT2ACA12 | |
| SCHEMBL11008658 | 0.62 | ALDH1A1 (0.62) | TSHRMAPTKMT2ACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10646595-B2 | Porphyrin compounds and their use as MRI contrast agents | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2020-05-12 | — | — | US | disclosed |
| US-20160235866-A1 | MRI CONTRAST AGENTS FOR CELL LABELING | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2016-08-18 | — | — | US | disclosed |
| WO-2015048912-A1 | MRI CONTRAST AGENTS FOR CELL LABELING | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2015-04-09 | — | — | WO | disclosed |
| US-20140227196-A1 | PORPHYRIN COMPOUNDS AND THEIR USE AS MRI CONTRAST AGENTS | THE HOSPITAL FOR SICK CHILDREN (CA) | 2014-08-14 | — | — | US | disclosed |
| US-20060128944-A1 | Molecular linkers suitable for crystallization and structural analysis of molecules of interest, method of using same, and methods of purifying g protein-coupled receptors | YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTRITUTE OF SCIENCE | 2006-06-15 | — | — | US | disclosed |
| EP-1071474-B1 | SUBSTITUTED PORPHYRINS | UNIV DUKE (US) | 2005-11-30 | — | — | EP | disclosed |
| EP-1478658-A2 | MOLECULAR LINKERS SUITABLE FOR CRYSTALLIZATION AND STRUCTURAL ANALYSIS OF MOLECULES OF INTEREST, METHOD OF USING SAME, AND METHODS OF PURIFYING G PROTEIN-COUPLED RECEPTORS | YEDA RESEARCH AND DEVELOPMENT Co. LTD. (IL) | 2004-11-24 | — | — | EP | disclosed |
| WO-2003016330-A2 | MOLECULAR LINKERS SUITABLE FOR CRYSTALLIZATION AND STRUCTURAL ANALYSIS OF MOLECULES OF INTEREST, METHOD OF USING SAME, AND METHODS OF PURIFYING G PROTEIN-COUPLED RECEPTORS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2003-02-27 | — | — | WO | disclosed |
| US-6479477-B1 | SUITABLE FOR USE IN MODULATING INTRA- AND EXTRACELLULAR PROCESSES IN WHICH SUPEROXIDE RADICALS, OR OTHER OXIDANTS SUCH AS HYDROGEN PEROXIDE OR PEROXYNITRITE, ARE A PARTICIPANT | DUKE UNIVERSITY | 2002-11-12 | — | — | US | disclosed |
| EP-1071474-A4 | SUBSTITUTED PORPHYRINS | UNIV DUKE (US) | 2002-10-24 | — | — | EP | disclosed |
| EP-1071474-A1 | SUBSTITUTED PORPHYRINS | DUKE UNIVERSITY (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999055388-A9 | SUBSTITUTED PORPHYRINS | UNIV DUKE (US) | 2000-01-27 | — | — | WO | disclosed |
| WO-1999055388-A1 | SUBSTITUTED PORPHYRINS | DUKE UNIVERSITY (US) | 1999-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160235866-A1 | MRI CONTRAST AGENTS FOR CELL LABELING | MPI, HMBS, TSPO | CYP1A2 1483/4885TSHR 3333/4885MAPT 3289/4885 |
| US-20140227196-A1 | PORPHYRIN COMPOUNDS AND THEIR USE AS MRI CONTRAST AGENTS | PML, HMBS, PPOX | CYP1A2 2669/4885TSHR 4312/4885MAPT 211/4885 |
| US-10646595-B2 | Porphyrin compounds and their use as MRI contrast agents | PML, HMBS, PPOX | CYP1A2 2669/4885TSHR 4312/4885MAPT 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.