Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | QPCT | Q16769 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PTAFR | P25105 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6414711 | 0.99 | ALDH1A1 (0.43) | ALDH1A1POLBL3MBTL1MAPTUSP2 | |
| SCHEMBL6417321 | 0.94 | ALDH1A1 (0.48) | ALDH1A1POLBL3MBTL1MAPTUSP2 | |
| Hydrochloric Acid SCHEMBL6417316 | 0.93 | ALDH1A1 (0.47) | ALDH1A1POLBL3MBTL1MAPTUSP2 | |
| SCHEMBL6409263 | 0.91 | ROCK2 (0.49) | ALDH1A1POLBMAPTROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL6409256 | 0.90 | ROCK2 (0.48) | ALDH1A1POLBMAPTROCK2ROCK1 | |
| SCHEMBL6417656 | 0.88 | POLB (0.41) | ALDH1A1POLBMAPTHCRTR2 | |
| SCHEMBL6409365 | 0.88 | MAPT (0.41) | ALDH1A1POLBMAPTROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL6417648 | 0.88 | POLB (0.41) | ALDH1A1POLBMAPTHCRTR2 | |
| Hydrochloric Acid SCHEMBL6409364 | 0.87 | MAPT (0.40) | ALDH1A1POLBMAPTROCK2ROCK1 | |
| SCHEMBL6415545 | 0.87 | ALDH1A1 (0.47) | ALDH1A1POLBL3MBTL1MAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA INC (CA) | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | CXCR1, CXCR4, CXCR2 | ALDH1A1 869/4885POLB 3564/4885L3MBTL1 3554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.