Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.60 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.59 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.57 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.56 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.56 |
| ▸ | NR4A3 | Q92570 | 2/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | CTSV | O60911 | 1/20 | 0.55 |
| ▸ | CTSL | P07711 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | PLAU | P00749 | 1/20 | 0.53 |
| ▸ | PLAT | P00750 | 1/20 | 0.53 |
| ▸ | MDH2 | P40926 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | DHODH | Q02127 | 1/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11908686 | 0.84 | SLC16A3 (0.56) | MRGPRX4ALOX5SLC16A3NR4A2NR4A1 | |
| SCHEMBL8597245 | 0.84 | HIF1A (0.52) | MRGPRX4ALOX5NR4A2NR4A1NR4A3 | |
| SCHEMBL8596749 | 0.84 | ALOX5 (0.51) | MRGPRX4ALOX5SLC16A3NR4A2NR4A1 | |
| SCHEMBL6564323 | 0.82 | PTPN7 (0.64) | NR4A2NR4A1NR4A3MCL1ALDH1A1 | |
| SCHEMBL7061258 | 0.82 | PTPN1 (0.68) | MRGPRX4ALOX5SLC16A3NR4A2CTSV | |
| SCHEMBL4489367 | 0.81 | MRGPRX4 (0.50) | MRGPRX4ALOX5NR4A2NR4A1NR4A3 | |
| SCHEMBL8596746 | 0.81 | ALOX5 (0.48) | MRGPRX4ALOX5SLC16A3NR4A2NR4A1 | |
| SCHEMBL8596757 | 0.81 | ALOX5 (0.48) | MRGPRX4ALOX5SLC16A3NR4A2NR4A1 | |
| SCHEMBL38662923 | 0.81 | ALOX5 (0.65) | MRGPRX4ALOX5NR4A2PLAUPLAT | |
| SCHEMBL22213623 | 0.80 | GFER (0.66) | MRGPRX4SLC16A3CTSVCTSLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090012-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |
| EP-1090012-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |