Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 3/20 | 0.37 |
| ▸ | ATP1A1 | P05023 | 4/20 | 0.37 |
| ▸ | ATP1B1 | P05026 | 4/20 | 0.37 |
| ▸ | ATP1A3 | P13637 | 4/20 | 0.37 |
| ▸ | ATP1B2 | P14415 | 4/20 | 0.37 |
| ▸ | ATP1A2 | P50993 | 4/20 | 0.37 |
| ▸ | ATP1B3 | P54709 | 4/20 | 0.37 |
| ▸ | FXYD2 | P54710 | 4/20 | 0.37 |
| ▸ | ATP1A4 | Q13733 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6414904 | 0.82 | PLK1 (0.46) | PLK1LCK | |
| SCHEMBL5314487 | 0.82 | PLK1 (0.46) | PLK1LCK | |
| SCHEMBL6417552 | 0.69 | ALDH1A1 (0.35) | NPC1RAB9AALDH1A1TSHRMAPK1 | |
| SCHEMBL6414447 | 0.68 | ALDH1A1 (0.36) | ALDH1A1TSHRMAPK1PLK1RPS6KB1 | |
| SCHEMBL13220952 | 0.68 | GSK3B (0.53) | ALDH1A1TSHRMAPK1IGF1R | |
| SCHEMBL5311550 | 0.67 | KDM4E (0.41) | NPC1RAB9AALDH1A1TSHRMAPK1 | |
| SCHEMBL6414308 | 0.65 | ALDH1A1 (0.37) | NPC1RAB9AALDH1A1TSHRMAPK1 | |
| SCHEMBL5318263 | 0.64 | MAPT (0.41) | MEN1NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL5311751 | 0.63 | ALDH1A1 (0.39) | NPC1RAB9AALDH1A1TSHRMAPK1 | |
| SCHEMBL5317535 | 0.63 | BPTF (0.46) | MEN1RAB9AKMT2AALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050288502-A1 | Substituted heterocyclic compounds and methods of use | AMGEN, INC. | 2005-12-29 | — | — | US | claimed |
| US-20050288502-A1 | Substituted heterocyclic compounds and methods of use | AMGEN, INC. | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288502-A1 | Substituted heterocyclic compounds and methods of use | MYLK2, IAPP, MAPT | MEN1 756/4885NPC1 3886/4885RAB9A 2169/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.