Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5314487 | 0.83 | PLK1 (0.46) | CAMK2DPLK1 | |
| SCHEMBL6414904 | 0.83 | PLK1 (0.46) | CAMK2DPLK1 | |
| SCHEMBL5318263 | 0.77 | MAPT (0.41) | ALDH1A1TSHRMAPK1KDM4ESMN1; SMN2 | |
| SCHEMBL5317535 | 0.76 | BPTF (0.46) | ALDH1A1TSHRMAPK1KDM4ESMN1; SMN2 | |
| SCHEMBL5311751 | 0.76 | ALDH1A1 (0.39) | ALDH1A1TSHRMAPK1KDM4ESMN1; SMN2 | |
| SCHEMBL6414897 | 0.73 | HTR7 (0.46) | KDM4ESMN1; SMN2HRH4HPGD | |
| SCHEMBL13220952 | 0.70 | GSK3B (0.53) | ALDH1A1TSHRMAPK1KDM4ESMN1; SMN2 | |
| SCHEMBL5311550 | 0.70 | KDM4E (0.41) | ALDH1A1TSHRMAPK1KDM4ESMN1; SMN2 | |
| SCHEMBL6415712 | 0.68 | MEN1 (0.39) | ALDH1A1TSHRMAPK1RPS6KB1PLK1 | |
| SCHEMBL6417552 | 0.64 | ALDH1A1 (0.35) | ALDH1A1TSHRMAPK1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050288502-A1 | Substituted heterocyclic compounds and methods of use | AMGEN, INC. | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288502-A1 | Substituted heterocyclic compounds and methods of use | MYLK2, IAPP, MAPT | ALDH1A1 3162/4885TSHR 2476/4885MAPK1 1274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.