Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.49 |
| ▸ | ADCY10 | Q96PN6 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7606821 | 0.88 | KDM4E (0.58) | NPSR1TLR8KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL10310928 | 0.88 | TLR8 (0.61) | NPSR1TLR8HPGDALDH1A1CDC7 | |
| SCHEMBL855005 | 0.84 | NPSR1 (0.69) | NPSR1TLR8KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL13686467 | 0.83 | CYP2D6 (0.54) | NPSR1KDM4EHPGDSMN1; SMN2ADCY10 | |
| SCHEMBL1900091 | 0.83 | CYP2D6 (0.59) | NPSR1TLR8ALDH1A1CDC7DBF4 | |
| SCHEMBL853400 | 0.81 | NPSR1 (1.00) | NPSR1KDM4EHPGDSMN1; SMN2PLA2G2A | |
| SCHEMBL2846939 | 0.80 | NPSR1 (0.64) | NPSR1TLR8KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL16229338 | 0.80 | KDM4E (0.48) | NPSR1TLR8KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL6420389 | 0.80 | TLR8 (0.55) | NPSR1TLR8HPGDPLA2G2AALDH1A1 | |
| SCHEMBL16229319 | 0.80 | KDM4E (0.48) | NPSR1KDM4EHPGDSMN1; SMN2ADCY10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180155298-A1 | PYRIMIDINE COMPOUNDS CONTAINING ACIDIC GROUPS | Apros Therapeutics, Inc. | 2018-06-07 | — | — | US | disclosed |
| CN-1255414-C | 2,4- dichlorophenoxy acetalimide derivatives of dithiazo pyridine with herbicidal activity and method for preparation thereof | UNIV SHANGHAI (CN) | 2006-05-10 | — | — | CN | disclosed |
| US-6951866-B2 | Bicyclic pyrimidine compounds and therapeutic use thereof | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2005-10-04 | — | — | US | disclosed |
| CN-1521169-A | 2,4- dichlorophenoxy acetalimide derivatives of dithiazo pyridine with herbicidal activity and method for preparation thereof | 上海师范大学 | 2004-08-18 | — | — | CN | disclosed |
| EP-1110951-B1 | PYRIMIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2004-05-19 | — | — | EP | disclosed |
| US-20030105323-A1 | Pyrimidine derivative | SUMITOMO PHARMACEUTICALS COMPANY LIMITED | 2003-06-05 | — | — | US | disclosed |
| US-6458798-B1 | HAS AN INHIBITORY ACTIVITY OF PRODUCTION OF TH2 TYPE CYTOKINES SUCH AS IL-4, IL-5, ETC., AND IS USEFUL AS AN THERAPEUTIC AGENT FOR ALLERGIC DISEASES, AUTOIMMUNE DISEASES SUCH AS SYSTEMIC LUPUS ERYTHEMATHOSUS, ETC., AND ACQUIRED | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2002-10-01 | — | — | US | disclosed |
| EP-1110951-A1 | PYRIMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-06-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180155298-A1 | PYRIMIDINE COMPOUNDS CONTAINING ACIDIC GROUPS | MAVS, TLR7, STING1 | NPSR1 3949/4885TLR8 16/4885KDM4E 3029/4885 |
| US-20030105323-A1 | Pyrimidine derivative | IL5, IL4, IL15 | NPSR1 1358/4885TLR8 209/4885KDM4E 1077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.