Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 6/20 | 0.36 |
| ▸ | FNTB | P49356 | 6/20 | 0.36 |
| ▸ | PGGT1B | P53609 | 5/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6448742 | 0.95 | FNTA (0.37) | FNTAFNTBPGGT1BIDO1LMNA | |
| SCHEMBL6413197 | 0.88 | FPR1 (0.32) | FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL6469829 | 0.85 | FNTA (0.38) | FNTAFNTBPGGT1BPTGDR2 | |
| SCHEMBL6416690 | 0.84 | FNTA (0.34) | FNTAFNTBPGGT1B | |
| SCHEMBL7165181 | 0.82 | FNTA (0.37) | FNTAFNTBPGGT1B | |
| Trifluoroacetic Acid SCHEMBL6410657 | 0.78 | FNTA (0.34) | FNTAFNTBPGGT1B | |
| SCHEMBL7164678 | 0.78 | FNTA (0.61) | FNTAFNTBPGGT1B | |
| SCHEMBL3500420 | 0.77 | FNTA (0.62) | FNTAFNTBPGGT1B | |
| SCHEMBL7166236 | 0.77 | FNTA (0.37) | FNTAFNTBPGGT1B | |
| Hydrochloric Acid SCHEMBL7592960 | 0.77 | FNTA (0.61) | FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090012-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |
| EP-1090012-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |