Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 4/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6411342 | 0.99 | HTT (0.43) | HTTCCR5SIGMAR1LIPGSLC6A2 | |
| SCHEMBL6409316 | 0.92 | SIGMAR1 (0.44) | HTTCCR5SIGMAR1UTS2RALDH1A1 | |
| SCHEMBL6415648 | 0.91 | CCR5 (0.41) | CCR5SIGMAR1UTS2RALDH1A1 | |
| Hydrochloric Acid SCHEMBL6413451 | 0.91 | SIGMAR1 (0.43) | HTTCCR5SIGMAR1UTS2RALDH1A1 | |
| Hydrochloric Acid SCHEMBL6414857 | 0.91 | CCR5 (0.41) | CCR5SIGMAR1UTS2RALDH1A1 | |
| SCHEMBL6409255 | 0.91 | CCR5 (0.49) | HTTCCR5SIGMAR1LIPGUTS2R | |
| SCHEMBL6417591 | 0.90 | SIGMAR1 (0.39) | CCR5SIGMAR1UTS2RALDH1A1 | |
| Hydrochloric Acid SCHEMBL6415252 | 0.90 | CCR5 (0.49) | HTTCCR5SIGMAR1LIPGUTS2R | |
| Hydrochloric Acid SCHEMBL6411335 | 0.89 | SIGMAR1 (0.39) | CCR5SIGMAR1UTS2RALDH1A1 | |
| SCHEMBL6416207 | 0.89 | CCR5 (0.46) | HTTCCR5SIGMAR1LIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA INC (CA) | 2005-04-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075326-A1 | Spiro compounds and methods for the modulation of chemokine receptor activity | CXCR1, CXCR4, CXCR2 | HTT 4137/4885CCR5 4/4885SIGMAR1 277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.