Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.42 |
| ▸ | HEXA | P06865 | 4/20 | 0.41 |
| ▸ | HEXB | P07686 | 4/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12496379 | 0.80 | TLR8 (0.47) | TLR8TLR7NOS2SMN1; SMN2 | |
| SCHEMBL19242058 | 0.80 | HEXA (0.47) | DHFRHEXAHEXBALDH1A1MEN1 | |
| SCHEMBL6415564 | 0.78 | TLR8 (0.39) | DHFRTLR8TLR7GABRPGABRD | |
| SCHEMBL13451266 | 0.76 | DHFR (0.35) | DHFRHEXAHEXBTLR8TLR7 | |
| SCHEMBL28043913 | 0.76 | TLR8 (0.44) | DHFRHEXAHEXBTLR8TLR7 | |
| SCHEMBL6416413 | 0.76 | TLR8 (0.56) | TLR8TLR7 | |
| SCHEMBL3830025 | 0.75 | TLR8 (0.49) | DHFRTLR8TLR7LMNASMN1; SMN2 | |
| Water SCHEMBL28123348 | 0.74 | TLR8 (0.49) | DHFRTLR8TLR7 | |
| SCHEMBL1091936 | 0.73 | DHFR (0.47) | DHFRHEXAHEXBTLR8TLR7 | |
| SCHEMBL12495463 | 0.73 | TLR8 (0.47) | DHFRTLR8TLR7ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6951866-B2 | Bicyclic pyrimidine compounds and therapeutic use thereof | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2005-10-04 | — | — | US | disclosed |
| EP-1110951-B1 | PYRIMIDINE DERIVATIVES | SUMITOMO PHARMA (JP) | 2004-05-19 | — | — | EP | disclosed |
| US-20030105323-A1 | Pyrimidine derivative | SUMITOMO PHARMACEUTICALS COMPANY LIMITED | 2003-06-05 | — | — | US | disclosed |
| US-6458798-B1 | HAS AN INHIBITORY ACTIVITY OF PRODUCTION OF TH2 TYPE CYTOKINES SUCH AS IL-4, IL-5, ETC., AND IS USEFUL AS AN THERAPEUTIC AGENT FOR ALLERGIC DISEASES, AUTOIMMUNE DISEASES SUCH AS SYSTEMIC LUPUS ERYTHEMATHOSUS, ETC., AND ACQUIRED | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2002-10-01 | — | — | US | disclosed |
| EP-1110951-A1 | PYRIMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2001-06-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105323-A1 | Pyrimidine derivative | IL5, IL4, IL15 | DHFR 161/4885HEXA 1095/4885HEXB 1292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.