Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 13/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.49 |
| ▸ | MAPT | P10636 | 12/20 | 0.49 |
| ▸ | GAA | P10253 | 11/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.45 |
| ▸ | DDX3X | O00571 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6440416 | 0.91 | MEN1 (0.47) | MEN1KMT2AMAPTGAAKDM4E | |
| SCHEMBL6432233 | 0.89 | GAA (0.44) | MEN1KMT2AMAPTGAAKDM4E | |
| SCHEMBL6432225 | 0.89 | GAA (0.44) | MEN1KMT2AMAPTGAAKDM4E | |
| SCHEMBL6431437 | 0.87 | MEN1 (0.50) | MEN1KMT2AMAPTGAAKDM4E | |
| SCHEMBL6432172 | 0.86 | GAA (0.47) | MEN1KMT2AMAPTGAAKDM4E | |
| SCHEMBL6417232 | 0.85 | DDX3X (0.49) | MEN1KMT2AMAPTGAAKDM4E | |
| SCHEMBL6414918 | 0.85 | DDX3X (0.63) | MEN1KMT2AMAPTGAAKDM4E | |
| SCHEMBL6412970 | 0.84 | MAPT (0.46) | MEN1KMT2AMAPTGAAKDM4E | |
| SCHEMBL6417041 | 0.82 | KMT2A (0.43) | MEN1KMT2AMAPTGAAKDM4E | |
| SCHEMBL6417039 | 0.82 | KMT2A (0.43) | MEN1KMT2AMAPTGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005044270-A1 | OXADIAZOLOPYRAZINE DERIVATIVES AS PHARMACEUTICALLY ACTIVE COMPOUNDS | 4SC AG (DE) | 2005-05-19 | — | — | WO | disclosed |
| EP-1529531-A1 | Oxadiazolopyrazine derivatives as pharmaceutically active compounds | 4SC AG (DE) | 2005-05-11 | — | — | EP | disclosed |