SCHEMBL6417161

SCHEMBL6417161

CC(C)[Si](Oc1ccc2cccc(I)c2c1)(C(C)C)C(C)C

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 3/20 0.35
MTNR1A P48039 6/20 0.33
NQO2 P16083 2/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33
ITK Q08881 1/20 0.32
MTNR1B P49286 1/20 0.32
KRAS P01116 1/20 0.31
C1R P00736 1/20 0.31
CYP1A2 P05177 2/20 0.31
CYP2A6 P11509 1/20 0.31
HTR1A P08908 1/20 0.31
HTR1D P28221 1/20 0.31
HTR1B P28222 1/20 0.31
ALDH1A1 P00352 1/20 0.30
HPGD P15428 1/20 0.30
HSD17B10 Q99714 1/20 0.30
TRPV1 Q8NER1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31670075 0.78 CYP2A6 (0.52) HTR2AHTR2CHTR2BCYP1A2CYP2A6
SCHEMBL6584082 0.78 MTNR1A (0.38) HTR2AMTNR1ANQO2HTR2CHTR2B
SCHEMBL7062446 0.77 CA12 (0.48) HTR2AMTNR1AMTNR1BC1RHTR1A
SCHEMBL6410573 0.77 MTNR1A (0.47) MTNR1ANQO2CYP1A2ALDH1A1HPGD
SCHEMBL30533124 0.76 CYP1A2 (0.55) HTR2AMTNR1ANQO2HTR2CHTR2B
SCHEMBL9037894 0.76 CYP1A2 (0.55) HTR2AMTNR1ANQO2HTR2CHTR2B
SCHEMBL6583218 0.76 HTR2A (0.49) HTR2AMTNR1ANQO2HTR2CHTR2B
SCHEMBL6582651 0.74 MTNR1A (0.52) MTNR1ANQO2HTR2CHTR2BMTNR1B
SCHEMBL9987304 0.73 SLC6A2 (0.36) HTR2C
SCHEMBL7062445 0.71 MTNR1A (0.31) HTR2AMTNR1ANQO2HTR1AHTR1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1090011-A4 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE MERCK & CO INC (US) 2005-04-06 EP disclosed
EP-1090012-A4 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE MERCK & CO INC (US) 2005-04-06 EP disclosed
US-6562823-B1 Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar MERCK & CO., INC. 2003-05-13 US disclosed
US-6441017-B1 Inhibitors of prenyl-protein transferase MERCK & CO., INC. 2002-08-27 US disclosed
US-6410534-B1 ANTICANCER AGENTS MERCK & CO., INC. 2002-06-25 US disclosed
EP-1214326-A1 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE Merck & Co., Inc. (US) 2002-06-19 EP disclosed
EP-1090012-A1 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE Merck & Co., Inc. (US) 2001-04-11 EP disclosed
EP-1090011-A1 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE Merck & Co., Inc. (US) 2001-04-11 EP disclosed
WO-2001018006-A1 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 2001-03-15 WO disclosed
WO-2000001701-A1 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 2000-01-13 WO disclosed
WO-2000001702-A1 INHIBITORS OF PRENYL-PROTEIN TRANSFERASE MERCK & CO., INC. (US) 2000-01-13 WO disclosed