Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 4/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15280121 | 0.78 | ACHE (0.52) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL31338350 | 0.78 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3APPIDO1 | |
| SCHEMBL1877066 | 0.77 | MAOB (0.42) | — | |
| SCHEMBL30903363 | 0.77 | ALDH1A1 (0.53) | APPTAAR1 | |
| SCHEMBL5735332 | 0.77 | CYP3A4 (0.47) | APP | |
| SCHEMBL7354814 | 0.75 | APP (0.35) | SLC6A4APP | |
| SCHEMBL706142 | 0.74 | CA4 (0.42) | — | |
| SCHEMBL7482659 | 0.74 | ACHE (0.36) | TAAR1 | |
| SCHEMBL255662 | 0.74 | KMT2A (0.47) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28707590 | 0.73 | IDO1 (0.36) | SLC6A2SLC6A4SLC6A3APPIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011158149-A1 | 2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES | PFIZER INC. (US) | 2011-12-22 | — | — | WO | disclosed |