⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11585314 | 0.86 | — | — | |
| Tert-Butyl Formate SCHEMBL27789517 | 0.79 | KDM4E (0.46) | — | |
| SCHEMBL440540 | 0.77 | — | — | |
| SCHEMBL1405881 | 0.77 | — | — | |
| SCHEMBL14023142 | 0.77 | — | — | |
| SCHEMBL1970431 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL3303102 | 0.76 | KDM4E (0.96) | — | |
| Hydrochloric Acid SCHEMBL4431863 | 0.76 | KDM4E (0.96) | — | |
| Hydrochloric Acid SCHEMBL2144603 | 0.76 | KDM4E (0.96) | — | |
| Hydrochloric Acid SCHEMBL2144598 | 0.76 | KDM4E (0.96) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10328064-B2 | Compositions of fatostatin based heterocyclic compounds and uses thereof | FGH BIOTECH, INC. (US) | 2019-06-25 | — | — | US | disclosed |
| CN-108864075-A | A kind of isothiazole connection thiazole and its preparation method and application | 南开大学 | 2018-11-23 | — | — | CN | disclosed |
| US-20180000801-A1 | COMPOSITIONS OF FATOSTATIN BASED HETEROCYCLIC COMPOUNDS AND USES THEREOF | Fgh Biotech Inc. | 2018-01-04 | — | — | US | disclosed |
| EP-3237413-A1 | COMPOSITIONS OF FATOSTATIN BASED HETEROCYCLIC COMPOUNDS AND USES THEREOF | FGH Biotech (US) | 2017-11-01 | — | — | EP | disclosed |
| WO-2016105491-A1 | COMPOSITIONS OF FATOSTATIN BASED HETEROCYCLIC COMPOUNDS AND USES THEREOF | FGH BIOTECH (US) | 2016-06-30 | — | — | WO | disclosed |
| CN-101932577-B | Heteroaryl-substituted piperidines | BAYER HEALTHCARE AG | 2013-07-17 | — | — | CN | disclosed |
| US-20120214788-A1 | HETEROARYL-SUBSTITUTED PIPERIDINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-08-23 | — | — | US | disclosed |
| US-8119663-B2 | Heteroaryl-substituted piperidines | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-02-21 | — | — | US | disclosed |
| CN-101932577-A | Heteroaryl-substituted piperidines | BAYER HEALTHCARE AG | 2010-12-29 | — | — | CN | disclosed |
| US-20090306139-A1 | HETEROARYL-SUBSTITUTED PIPERIDINES | BAYER HEALTHCARE AG (DE) | 2009-12-10 | — | — | US | disclosed |
| US-5834499-A | TREATING GASTROINTESTINAL DISORDERS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1998-11-10 | — | — | US | disclosed |
| CN-1143364-A | 5-HT3 receptor agonist, novel thiazole derivative, and intermediate thereof | YAMANOUCHI PHARMA CO LTD (JP) | 1997-02-19 | — | — | CN | disclosed |
| EP-0749966-A1 | 5-HT 3 RECEPTOR AGONIST, NOVEL THIAZOLE DERIVATIVE, AND INTERMEDIATE THEREFOR | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1996-12-27 | — | — | EP | disclosed |