Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 6/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | POLA1 | P09884 | 1/20 | 0.50 |
| ▸ | POLD1 | P28340 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23440065 | 0.91 | TK1 (0.67) | TK1POLBPOLA1POLD1 | |
| SCHEMBL26757571 | 0.91 | TK1 (0.67) | TK1POLBPOLA1POLD1 | |
| SCHEMBL28774920 | 0.91 | TK1 (0.67) | TK1POLBPOLA1POLD1 | |
| SCHEMBL8883 | 0.91 | TK1 (0.67) | TK1POLBPOLA1POLD1 | |
| SCHEMBL13245040 | 0.90 | TK1 (0.57) | TK1POLBPOLA1POLD1BCHE | |
| SCHEMBL16217853 | 0.89 | TK1 (0.56) | TK1POLBPOLA1POLD1BCHE | |
| SCHEMBL23440064 | 0.89 | TK1 (0.54) | TK1POLBPOLA1POLD1BCHE | |
| SCHEMBL14279195 | 0.88 | TK1 (0.55) | TK1POLBPOLA1POLD1BCHE | |
| SCHEMBL26757239 | 0.88 | TK1 (0.55) | TK1POLBPOLA1POLD1BCHE | |
| SCHEMBL2696427 | 0.88 | TK1 (0.54) | TK1POLBPOLA1POLD1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6939689-B2 | Exonuclease-mediated nucleic acid reassembly in directed evolution | DIVERSA CORPORATION (US) | 2005-09-06 | — | — | US | disclosed |
| US-20040152077-A1 | EXONUCLEASE-MEDIATED NUCLEIC ACID REASSEMBLY IN DIRECTED EVOLUTION | VERENIUM CORPORATION | 2004-08-05 | — | — | US | disclosed |
| US-6740506-B2 | GENERATING MUTANT POLYPEPTIDES; OBTAIN PROTEIN SAMPLE, INCUBATE WIH MUTAGEN, RECOVER AND EVALUATE PROTEIN ACTIVITY | DIVERSA CORPORATION | 2004-05-25 | — | — | US | disclosed |
| US-6635449-B2 | Can be used in combination with other mutagenesis methods | DIVERSA CORPORATION | 2003-10-21 | — | — | US | disclosed |
| US-20030036116-A1 | Exonuclease-mediated nucleic acid reassembly in directed evolution | DIVERSA CORPORATION | 2003-02-20 | — | — | US | disclosed |
| US-20020146762-A1 | End selection in directed evolution | BP CORPORATION NORTH AMERICA INC. | 2002-10-10 | — | — | US | disclosed |