Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | XDH | P47989 | 3/20 | 0.45 |
| ▸ | TYMP | P19971 | 1/20 | 0.44 |
| ▸ | HINT1 | P49773 | 2/20 | 0.39 |
| ▸ | PNP | P00491 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HBB | P68871 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6001972 | 0.93 | HPGD (0.47) | HPGDXDHTYMPHINT1PNP | |
| SCHEMBL1904551 | 0.93 | PNP (0.44) | HPGDXDHHINT1PNPTAAR1 | |
| SCHEMBL1068353 | 0.83 | ADORA2A (0.41) | TYMPADORA3ADORA2AADORA2B | |
| SCHEMBL7191547 | 0.83 | TAAR1 (0.37) | HPGDXDHHINT1PNPTAAR1 | |
| SCHEMBL1068569 | 0.83 | ADORA1 (0.44) | MEN1KMT2AADORA3ADORA2AADORA2B | |
| SCHEMBL16496887 | 0.83 | TYMP (0.35) | HPGDXDHTYMPADORA3ADORA2A | |
| SCHEMBL17440174 | 0.80 | ADORA3 (0.46) | HPGDHINT1PNPMEN1KMT2A | |
| SCHEMBL10446695 | 0.80 | XDH (0.37) | HPGDXDHHINT1PNPTAAR1 | |
| SCHEMBL30514383 | 0.79 | KDM4E (0.42) | HPGDTYMPTAAR1 | |
| SCHEMBL3810729 | 0.79 | HPGD (0.42) | HPGDXDHHINT1PNPMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567009-A2 | ANTISENSE MODULATION OF NOTCH (DROSOPHILA) HOMOLOG 4 EXPRESSION | Isis Pharmaceuticals, Inc. (US) | 2005-08-31 | — | — | EP | disclosed |
| EP-1501854-A2 | ANTISENSE MODULATION OF HMGI-C EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2005-02-02 | — | — | EP | disclosed |
| EP-1501941-A1 | ANTISENSE MODULATION OF JAGGED 2 EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2005-02-02 | — | — | EP | disclosed |
| EP-1461349-A2 | ANTISENSE MODULATION OF MHC CLASS II TRANSACTIVATOR EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-1461419-A2 | ANTISENSE MODULATION OF PHOSPHOLIPID SCRAMBLASE 3 EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-1461461-A2 | ANTISENSE MODULATION OF CD81 EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2004-09-29 | — | — | EP | disclosed |
| EP-1451363-A2 | ANTISENSE MODULATION OF THYROID HORMONE RECEPTOR INTERACTOR 6 EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2004-09-01 | — | — | EP | disclosed |
| EP-1436310-A1 | ANTISENSE MODULATION OF VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2004-07-14 | — | — | EP | disclosed |
| EP-1417216-A2 | ANTISENSE MODULATION OF BCL2-ASSOCIATED X PROTEIN EXPRESSION | ISIS Pharmaceuticals, Inc. (US) | 2004-05-12 | — | — | EP | disclosed |
| EP-1417339-A2 | ANTISENSE MODULATION OF GLIOMA-ASSOCIATED ONCOGENE-2 EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003008543-A2 | ANTISENSE MODULATION OF BCL2-ASSOCIATED X PROTEIN EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2003-01-30 | — | — | WO | disclosed |
| WO-2003008545-A2 | ANTISENSE MODULATION OF GLIOMA-ASSOCIATED ONCOGENE-2 EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2003-01-30 | — | — | WO | disclosed |
| WO-2003008544-A2 | ANTISENSE MODULATION OF TRANSFORMING GROWTH FACTOR-BETA 3 EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2003-01-30 | — | — | WO | disclosed |
| WO-2003000656-A2 | ANTISENSE MODULATION OF TRANSFORMING GROWTH FACTOR BETA RECEPTOR II EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2003-01-03 | — | — | WO | disclosed |
| WO-2002097108-A2 | ANTISENSE MODULATION OF DUAL SPECIFIC PHOSPHATASE 5 EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2002-12-05 | — | — | WO | disclosed |
| WO-2002092855-A1 | ANTISENSE MODULATION OF HELICASE-MOI EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2002-11-21 | — | — | WO | disclosed |
| WO-2002088392-A1 | ANTISENSE MODULATION OF GU PROTEIN EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2002-11-07 | — | — | WO | disclosed |
| WO-2002088162-A1 | ANTISENSE MODULATION OF INTERFERON GAMMA RECEPTOR 1 EXPRESSION | ISIS PHARMACEUTICALS, INC (US) | 2002-11-07 | — | — | WO | disclosed |
| WO-2002088393-A1 | ANTISENSE MODULATION OF TUMOR NECROSIS FACTOR RECEPTOR 2 EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2002-11-07 | — | — | WO | disclosed |
| WO-2001071008-A1 | ANTISENSE INHIBITION OF ADAM10 EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2001-09-27 | — | — | WO | disclosed |