Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1433585 | 0.85 | CHRM3 (0.36) | ELANEHTR6S1PR1PNMT | |
| SCHEMBL1434446 | 0.82 | ADORA1 (0.35) | HTR6S1PR1MAPTPNMT | |
| SCHEMBL1433350 | 0.81 | S1PR1 (0.40) | ELANEHTR6S1PR1PNMT | |
| SCHEMBL16373419 | 0.80 | ELANE (0.52) | ELANENR1H2FAAHESR2MAPT | |
| SCHEMBL1434695 | 0.79 | PLAT (0.33) | ELANEHTR6S1PR1PNMT | |
| SCHEMBL1433863 | 0.78 | HTR6 (0.31) | HTR6S1PR1 | |
| SCHEMBL827484 | 0.78 | ELANE (0.50) | ELANENR1H2MAPK1FAAHESR2 | |
| SCHEMBL28276822 | 0.74 | BUB1 (0.46) | NR1H2MAPK1ESR2PNMT | |
| SCHEMBL28361733 | 0.73 | ELANE (0.54) | ELANENR1H2FAAHMAPTHTT | |
| SCHEMBL29207748 | 0.72 | ELANE (0.47) | ELANENR1H2FAAHESR2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |