Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | F12 | P00748 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1433995 | 0.91 | ALDH1A1 (0.33) | ADORA1SLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL1434695 | 0.91 | PLAT (0.33) | HTR6F12S1PR1PNMTPLAT | |
| SCHEMBL29507376 | 0.87 | KMT2A (0.35) | LMNAKMT2AALDH1A1MEN1GAA | |
| SCHEMBL1433863 | 0.87 | HTR6 (0.31) | HTR6S1PR1TSHR | |
| SCHEMBL1433585 | 0.86 | CHRM3 (0.36) | HTR6S1PR1PNMT | |
| SCHEMBL6420852 | 0.82 | ELANE (0.48) | HTR6S1PR1MAPTPNMT | |
| SCHEMBL1433350 | 0.82 | S1PR1 (0.40) | HTR6F12S1PR1PNMTPLAT | |
| SCHEMBL8132784 | 0.80 | SMN1; SMN2 (0.43) | KMT2AALDH1A1MEN1GAATSHR | |
| Hydrochloric Acid SCHEMBL7988687 | 0.79 | SMN1; SMN2 (0.42) | LMNAKMT2AALDH1A1MEN1GAA | |
| Hydrochloric Acid SCHEMBL7975255 | 0.79 | SMN1; SMN2 (0.42) | LMNAKMT2AALDH1A1MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2300436-A1 | CARBAMOYL DERIVATIVES OF BICYCLIC CARBONYLAMINO-PYRAZOLES AS PRODRUGS | Nerviano Medical Sciences S.r.l. (IT) | 2011-03-30 | — | — | EP | claimed |
| EP-2300436-A1 | CARBAMOYL DERIVATIVES OF BICYCLIC CARBONYLAMINO-PYRAZOLES AS PRODRUGS | Nerviano Medical Sciences S.r.l. (IT) | 2011-03-30 | — | — | EP | disclosed |