Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.61 |
| ▸ | RET | P07949 | 2/20 | 0.61 |
| ▸ | PIM1 | P11309 | 2/20 | 0.61 |
| ▸ | KDR | P35968 | 2/20 | 0.61 |
| ▸ | GSK3A | P49840 | 2/20 | 0.61 |
| ▸ | GSK3B | P49841 | 2/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.61 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.61 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.61 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.61 |
| ▸ | AURKA | O14965 | 1/20 | 0.61 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.61 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | PAK4 | O96013 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31425375 | 0.76 | PRKD3 (0.61) | RPS6KA3PRKD3MAP4K4RETPIM1 | |
| SCHEMBL13290171 | 0.76 | PRKD3 (0.61) | RPS6KA3PRKD3MAP4K4RETPIM1 | |
| SCHEMBL481676 | 0.76 | DYRK1A (1.00) | RPS6KA3PRKD3MAP4K4RETPIM1 | |
| SCHEMBL13564022 | 0.76 | PRKD3 (0.61) | RPS6KA3PRKD3MAP4K4RETPIM1 | |
| SCHEMBL8199342 | 0.76 | PRKD3 (0.61) | RPS6KA3PRKD3MAP4K4RETPIM1 | |
| SCHEMBL30555653 | 0.74 | PRKD3 (0.54) | RPS6KA3PRKD3MAP4K4RETPIM1 | |
| SCHEMBL30176559 | 0.73 | PRKD3 (0.64) | RPS6KA3PRKD3MAP4K4RETPIM1 | |
| SCHEMBL23773948 | 0.72 | PRKD3 (0.56) | RPS6KA3PRKD3MAP4K4RETPIM1 | |
| SCHEMBL6813381 | 0.72 | PRKD3 (0.56) | RPS6KA3PRKD3MAP4K4RETPIM1 | |
| SCHEMBL22160853 | 0.72 | PRKD3 (0.56) | RPS6KA3PRKD3MAP4K4RETPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004133-A1 | Modulators of VR1 receptor | VERTEX PHARMACEUTICALS INCORPORATED | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004133-A1 | Modulators of VR1 receptor | TRPV1, TRPV2, TRPV3 | RPS6KA3 2006/4885PRKD3 1389/4885MAP4K4 2093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.