Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 9/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | CASP7 | P55210 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.51 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.51 |
| ▸ | KRAS | P01116 | 1/20 | 0.50 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6482626 | 0.92 | PTGDR2 (0.64) | PTGDR2CYP2C9HDAC1HDAC6KDM4E | |
| SCHEMBL6421798 | 0.91 | HDAC1 (0.55) | PTGDR2CYP2C9HDAC1HDAC6KDM4E | |
| SCHEMBL2086484 | 0.91 | PTGDR2 (0.72) | PTGDR2CYP2C9HDAC1HDAC6KDM4E | |
| SCHEMBL6423329 | 0.90 | HDAC1 (0.55) | PTGDR2CYP2C9HDAC1HDAC6KRAS | |
| SCHEMBL4185797 | 0.89 | HDAC1 (0.56) | PTGDR2CYP2C9HDAC1HDAC6HSD17B10 | |
| SCHEMBL6423858 | 0.89 | HDAC1 (0.53) | PTGDR2CYP2C9HDAC1HDAC6KRAS | |
| SCHEMBL6424243 | 0.89 | HDAC1 (0.55) | PTGDR2HDAC1HDAC6KRASCHRM2 | |
| SCHEMBL6421345 | 0.88 | HDAC1 (0.67) | HDAC1HDAC6 | |
| SCHEMBL6421118 | 0.87 | HDAC1 (0.55) | PTGDR2HDAC1HDAC6KRASENPP2 | |
| SCHEMBL6420742 | 0.85 | HDAC1 (0.54) | HDAC1HDAC6KRASENPP2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |