Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.52 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6421224 | 0.91 | HTR6 (0.56) | HTR6HTR2AHTR2CHDAC6HDAC1 | |
| Trifluoroacetic Acid SCHEMBL6422813 | 0.88 | HTR6 (0.49) | HTR6HTR2AHTR2CHDAC6HDAC1 | |
| Trifluoroacetic Acid SCHEMBL6422250 | 0.87 | HTR6 (0.46) | HTR6HTR2AHTR2CHDAC6HDAC1 | |
| Trifluoroacetic Acid SCHEMBL6421287 | 0.87 | HTR6 (0.46) | HTR6HTR2AHTR2CHDAC6HDAC1 | |
| Trifluoroacetic Acid SCHEMBL6421276 | 0.87 | P2RX4 (0.47) | HTR6HTR2AHTR2CHDAC6HDAC1 | |
| Trifluoroacetic Acid SCHEMBL968555 | 0.85 | HTR2A (0.60) | HTR6HTR2AHTR2CHDAC6HDAC1 | |
| Trifluoroacetic Acid SCHEMBL6424059 | 0.83 | HDAC6 (0.52) | HTR6HTR2AHTR2CHDAC6HDAC1 | |
| SCHEMBL5373439 | 0.82 | HTR6 (0.58) | HTR6HTR2AHTR2CHDAC6HDAC1 | |
| Trifluoroacetic Acid SCHEMBL6423027 | 0.79 | HDAC6 (0.67) | HTR6HDAC6HDAC1ALDH1A1TSHR | |
| Trifluoroacetic Acid SCHEMBL6422091 | 0.79 | HDAC6 (0.48) | HTR6HTR2AHTR2CHDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |