Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 4/20 | 0.41 |
| ▸ | DAGLA | Q9Y4D2 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5860684 | 0.82 | DAGLA (0.44) | LMNACES1FAAHDAGLA | |
| SCHEMBL6423056 | 0.79 | LMNA (0.44) | LMNAKDM4EHTTSMN1; SMN2ALOX12 | |
| SCHEMBL29291621 | 0.75 | KEAP1 (0.58) | LMNAKDM4EHTTSMN1; SMN2ALOX12 | |
| SCHEMBL18958933 | 0.75 | KEAP1 (0.58) | LMNAKDM4EHTTSMN1; SMN2ALOX12 | |
| SCHEMBL3413877 | 0.73 | KEAP1 (0.60) | LMNAKDM4EHTTSMN1; SMN2ALOX12 | |
| SCHEMBL8605049 | 0.72 | CYP1A2 (0.43) | LMNAKDM4EHTTSMN1; SMN2ALOX12 | |
| SCHEMBL1254914 | 0.72 | LMNA (0.63) | LMNAKDM4EHTTSMN1; SMN2ALOX12 | |
| SCHEMBL9440127 | 0.72 | LMNA (0.63) | LMNAKDM4EHTTSMN1; SMN2ALOX12 | |
| SCHEMBL17817131 | 0.72 | LMNA (0.63) | LMNAKDM4EHTTSMN1; SMN2ALOX12 | |
| SCHEMBL28247961 | 0.72 | LMNA (0.63) | LMNAKDM4EHTTSMN1; SMN2ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050287594-A1 | Activity-based probes having specificity to the active form of enzymes and receptors; screening for desired biological activities or target proteins | SCRIPPS RESEARCH INSTITUTE, THE | 2005-12-29 | — | — | US | disclosed |
| US-6872574-B2 | Generating and screening compound libraries that are used for the identification of lead molecules, and for the parallel identification of their biological targets | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-03-29 | — | — | US | disclosed |
| EP-1275006-A2 | PROTEOMIC ANALYSIS USING ACTIVITY-BASED PROBE LIBRARIES | The Scripps Research Institute (US) | 2003-01-15 | — | — | EP | disclosed |
| US-20020182652-A1 | Proteomic analysis | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2002-12-05 | — | — | US | disclosed |
| US-20020064799-A1 | Proteomic analysis | THE SCRIPPS RESEARCH INSTITUTE OF AN ASSIGNMENT | 2002-05-30 | — | — | US | disclosed |
| US-20020045194-A1 | Proteomic analysis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-04-18 | — | — | US | disclosed |
| US-20020040275-A1 | Proteomic analysis | THE SCRIPPS RESEARCH INSTITUTE | 2002-04-04 | — | — | US | disclosed |
| WO-2001077668-A2 | PROTEOMIC ANALYSIS USING ACTIVE-SITE DIRECTED PROBES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2001-10-18 | — | — | WO | disclosed |
| WO-2001077684-A2 | PROTEOMIC ANALYSIS USING ACTIVITY-BASED PROBE LIBRARIES | THE SCRIPPS RESEARCH INSTITUTE (US) | 2001-10-18 | — | — | WO | disclosed |