Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.42 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24187402 | 0.79 | SIGMAR1 (0.65) | SIGMAR1SMARCA2SMARCA4PBRM1SCN9A | |
| SCHEMBL6423389 | 0.75 | BCHE (0.46) | SIGMAR1SMARCA2SMARCA4PBRM1SCN9A | |
| SCHEMBL2016857 | 0.74 | MAPK1 (0.53) | SIGMAR1SMARCA2SMARCA4PBRM1SCN9A | |
| SCHEMBL6422038 | 0.74 | SIGMAR1 (0.46) | SIGMAR1SMARCA2SMARCA4PBRM1SCN9A | |
| SCHEMBL24187416 | 0.74 | SCN9A (0.49) | SIGMAR1SMARCA2SMARCA4PBRM1SCN9A | |
| SCHEMBL1350836 | 0.73 | SIGMAR1 (0.45) | SIGMAR1SMARCA2SMARCA4PBRM1SCN9A | |
| SCHEMBL1351241 | 0.73 | SIGMAR1 (0.50) | SIGMAR1SMARCA2SMARCA4PBRM1SCN9A | |
| SCHEMBL2013375 | 0.73 | SIGMAR1 (0.45) | SIGMAR1SMARCA2SMARCA4PBRM1SCN9A | |
| SCHEMBL24187263 | 0.73 | STS (0.46) | SIGMAR1SMARCA2SMARCA4PBRM1SCN9A | |
| SCHEMBL3940077 | 0.71 | USP30 (0.49) | SIGMAR1USP30GPR119JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |