Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4463271 | 0.97 | LMNA (0.68) | LMNASLC6A4SLC6A2SLC6A3HSD17B10 | |
| SCHEMBL2905656 | 0.89 | LMNA (0.56) | LMNASLC6A4SLC6A2SLC6A3HSD17B10 | |
| SCHEMBL11251072 | 0.85 | SLC6A4 (0.55) | LMNASLC6A4SLC6A2SLC6A3HSD17B10 | |
| SCHEMBL9277493 | 0.84 | LMNA (0.71) | LMNAHSD17B10NPSR1ALDH1A1PKM | |
| SCHEMBL8234489 | 0.84 | LMNA (0.51) | LMNASLC6A4SLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL9164273 | 0.82 | TACR1 (0.51) | LMNASLC6A4SLC6A2SLC6A3 | |
| SCHEMBL9515787 | 0.81 | LMNA (0.72) | LMNAHSD17B10NPSR1ALDH1A1PKM | |
| SCHEMBL4434773 | 0.81 | LMNA (0.68) | LMNAHSD17B10NPSR1ALDH1A1PKM | |
| SCHEMBL4039568 | 0.81 | SLC6A4 (0.51) | LMNASLC6A4SLC6A2SLC6A3HSD17B10 | |
| SCHEMBL4143905 | 0.81 | LMNA (0.71) | LMNASLC6A2SLC6A3HSD17B10NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047677-B1 | Process for the preparation of derivatives of 1,4,7,10-tetraazacyclododecane-1,4-diacetic acid | BRACCO SPA (IT) | 2005-07-20 | — | — | EP | claimed |
| EP-1602649-A2 | 1,4,7,10-TETRAAZACYCLODODECANE-1,4-DIACETIC ACID DERIVATIVES AS CHELATING AGENTS | BRACCO S.p.A. (IT) | 2005-12-07 | — | — | EP | disclosed |
| EP-1047677-B1 | Process for the preparation of derivatives of 1,4,7,10-tetraazacyclododecane-1,4-diacetic acid | BRACCO SPA (IT) | 2005-07-20 | — | — | EP | disclosed |
| US-6342597-B1 | CONDENSATION REACTION TRIETHYLENETETRAMINE WITH GLYOXAL TO CYCLIZE; OXIDATION, ALKYLATION, HYDROLYSIS, QUATERNIZATION; NUCLEAR MAGNETIC RESONANCE IMAGING | DIBRA S.P.A. (IT) | 2002-01-29 | — | — | US | disclosed |