Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4257189 | 0.86 | POLB (0.77) | POLBCYP3A4CYP2C9 | |
| SCHEMBL9714073 | 0.84 | POLB (0.85) | POLBCYP3A4CYP2C9HPGDSMN1; SMN2 | |
| SCHEMBL9714077 | 0.84 | POLB (0.85) | POLBCYP3A4CYP2C9HPGDSMN1; SMN2 | |
| SCHEMBL6421565 | 0.76 | PTPN1 (0.58) | POLBHPGDSMN1; SMN2 | |
| SCHEMBL6421890 | 0.76 | POLB (0.58) | POLBCYP3A4CYP2C9HPGDSMN1; SMN2 | |
| SCHEMBL9180922 | 0.76 | CYP3A4 (0.47) | POLBCYP3A4CYP2C9 | |
| SCHEMBL10720343 | 0.75 | ABCB1 (0.74) | POLBCYP3A4CYP2C9HPGDSMN1; SMN2 | |
| Rh-5849 SCHEMBL1538531 | 0.74 | POLB (1.00) | POLBCYP3A4CYP2C9HPGDSMN1; SMN2 | |
| SCHEMBL8174887 | 0.74 | POLB (0.75) | POLBCYP3A4CYP2C9 | |
| SCHEMBL6800377 | 0.74 | GFER (0.54) | POLBCYP3A4HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043388-A1 | Oxindole hydrazide modulators of protein tyrosine phosphatases (ptps) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. | 2005-02-24 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043388-A1 | Oxindole hydrazide modulators of protein tyrosine phosphatases (ptps) | PTPRO, PTPRE, PTPRZ1 | POLB 4789/4885CYP3A4 1654/4885CYP2C9 1510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.