Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 2/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31097086 | 0.83 | L3MBTL1 (0.48) | ALDH1A1SMN1; SMN2L3MBTL1POLBMEN1 | |
| SCHEMBL6679132 | 0.83 | KDM4E (0.48) | ALDH1A1GBA1SLC2A1POLBMEN1 | |
| SCHEMBL6673982 | 0.81 | HTT (0.49) | KDM4E | |
| SCHEMBL6679519 | 0.80 | KDM4E (0.40) | KDM4E | |
| SCHEMBL6365368 | 0.80 | POLB (0.49) | ALDH1A1SMN1; SMN2L3MBTL1SLC2A1POLB | |
| SCHEMBL6675351 | 0.79 | HRH3 (0.44) | MEN1KMT2A | |
| SCHEMBL31097089 | 0.77 | L3MBTL1 (0.50) | ALDH1A1SMN1; SMN2L3MBTL1POLBMEN1 | |
| SCHEMBL2245398 | 0.76 | CA12 (0.37) | ALDH1A1SMN1; SMN2L3MBTL1GBA1POLB | |
| SCHEMBL6426203 | 0.75 | CA12 (0.40) | ALDH1A1SMN1; SMN2L3MBTL1ADORA1GBA1 | |
| SCHEMBL6690674 | 0.74 | NR4A2 (0.35) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050153961-A1 | 1, 2, 4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents | LEE WILLIAM W (US) | 2005-07-14 | — | — | US | disclosed |
| US-6828321-B2 | Compounds specifically radiosensitize hypoxic tumor cells | SRI INTERNATIONAL | 2004-12-07 | — | — | US | disclosed |
| US-20020103200-A1 | 1,2,4-Benzotriazine oxides as radiosensitizers and selective cytotoxic agents | LEE WILLIAM W (US) | 2002-08-01 | — | — | US | disclosed |
| US-6362184-B1 | KILLING TUMOR CELLS | SRI INTERNATIONAL | 2002-03-26 | — | — | US | disclosed |
| US-5849738-A | 1,2,4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents | SRI INTERNATIONAL (US) | 1998-12-15 | — | — | US | disclosed |
| US-5624925-A | RADIOACTIVE MATERIALS FOR TUMOR DETECTION | SRI INTERNATIONAL (US) | 1997-04-29 | — | — | US | disclosed |
| US-5616584-A | ADMINISTERING A SENSITIZER PRIOR ANTITUMOR RADIATION THERAPY | SRI INTERNATIONAL (US) | 1997-04-01 | — | — | US | disclosed |
| US-5175287-A | Lower alkyl nitrite under reductive deamination | S R I INTERNATIONAL (US) | 1992-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020103200-A1 | 1,2,4-Benzotriazine oxides as radiosensitizers and selective cytotoxic agents | HYOU1, HIF1AN, HIF1A | ALDH1A1 444/4885SMN1; SMN2 3105/4885L3MBTL1 2457/4885 |
| US-20050153961-A1 | 1, 2, 4-benzotriazine oxides as radiosensitizers and selective cytotoxic agents | HYOU1, HIF1AN, HIF1A | ALDH1A1 444/4885SMN1; SMN2 3105/4885L3MBTL1 2457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.