Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.54 |
| ▸ | XDH | P47989 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 4/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4816031 | 0.88 | KDM4E (0.64) | PDGFRBPDGFRAXDHKDM4EALDH1A1 | |
| SCHEMBL2659656 | 0.87 | XDH (0.57) | PDGFRBPDGFRAXDHKDM4EALDH1A1 | |
| SCHEMBL6422580 | 0.86 | PDGFRB (0.54) | PDGFRBPDGFRAXDHKDM4EALDH1A1 | |
| SCHEMBL17775019 | 0.84 | KDM4E (0.60) | PDGFRBPDGFRAXDHKDM4EALDH1A1 | |
| SCHEMBL17775020 | 0.84 | KDM4E (0.60) | PDGFRBPDGFRAXDHKDM4EALDH1A1 | |
| SCHEMBL17775017 | 0.84 | KDM4E (0.60) | PDGFRBPDGFRAXDHKDM4EALDH1A1 | |
| SCHEMBL17775018 | 0.84 | KDM4E (0.60) | PDGFRBPDGFRAXDHKDM4EALDH1A1 | |
| SCHEMBL15222304 | 0.84 | PDGFRB (0.51) | PDGFRBPDGFRAXDHKDM4EALDH1A1 | |
| SCHEMBL17775023 | 0.84 | KDM4E (0.60) | PDGFRBPDGFRAXDHKDM4EALDH1A1 | |
| SCHEMBL17775016 | 0.84 | KDM4E (0.60) | PDGFRBPDGFRAXDHKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005118584-A2 | SAFRAMYCIN ANALOGS AS THERAPEUTIC AGENTS IN THE TREATMENT OF CANCER | AXYS PHARMACEUTICALS, INC. (US) | 2005-12-15 | — | — | WO | disclosed |