SCHEMBL642263

SCHEMBL642263

O=C1Cc2ccccc2C=N1

nearest known ligand 0.59

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 14/20 0.59
CYP1A2 P05177 1/20 0.41
MAOA P21397 2/20 0.39
MAOB P27338 1/20 0.39
CYP2A6 P11509 1/20 0.35
BCHE P06276 1/20 0.34
CES1 P23141 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29911790 1.00 TRPA1 (0.59) TRPA1CYP1A2MAOAMAOBCYP2A6
Hydrochloric Acid SCHEMBL11023474 0.98 TRPA1 (0.57) TRPA1CYP1A2MAOAMAOBCYP2A6
SCHEMBL3707900 0.79 TRPA1 (0.46) TRPA1CYP1A2MAOAMAOBCYP2A6
Morphanthridine SCHEMBL1150250 0.74 TRPA1 (1.00) TRPA1
SCHEMBL3632749 0.74 TRPA1 (0.59) TRPA1MAOAMAOB
SCHEMBL14361835 0.74 TRPA1 (0.53) TRPA1CYP1A2MAOAMAOB
SCHEMBL4202476 0.74 TRPA1 (0.53) TRPA1CYP1A2MAOAMAOB
Morphanthridine SCHEMBL1509656 0.72 TRPA1 (0.96) TRPA1
SCHEMBL1725093 0.72 PARP1 (0.32) TRPA1
SCHEMBL8115304 0.72 TRPA1 (0.32) TRPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116874481-A 1-phenyl-pyrrole [1,2-b ] isoquinoline-3-ketone compound and application thereof 贵州省天然产物研究中心 2023-10-13 CN claimed
CN-110204491-B Synthesis method of chiral 3, 4-dihydroisoquinolinone compound 台州学院 2021-02-19 CN claimed
EP-2588104-B1 ISOINDOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS MERCK SHARP & DOHME (US) 2014-12-10 EP claimed
CN-1218472-A Pharmaceutically useful compounds ASTRA PHARMA PROD (GB) 1999-06-02 CN claimed
EP-0457243-A1 Novel tricyclic compounds SYNTEX (U.S.A.) INC. (US) 1991-11-21 EP claimed
EP-4323356-A1 AMINO-SUBSTITUTED HETEROCYCLES FOR TREATING CANCERS WITH EGFR MUTATIONS Nuvalent, Inc. (US) 2024-02-21 EP disclosed
WO-2024015262-A1 FUSED RING KRAS INHIBITORS FOR TREATING DISEASE BLOSSOMHILL THERAPEUTICS, INC. (US) 2024-01-18 WO disclosed
CN-114163385-B Method for promoting oxidation of tetrahydroisoquinoline compounds to lactam compounds by using surfactant 新乡市润宇新材料科技有限公司 2023-11-24 CN disclosed
CN-116874481-A 1-phenyl-pyrrole [1,2-b ] isoquinoline-3-ketone compound and application thereof 贵州省天然产物研究中心 2023-10-13 CN disclosed
WO-2023173014-A1 KRAS INHIBITORS AND THEIR USE BLOSSOMHILL THERAPEUTICS, INC. (US) 2023-09-14 WO disclosed
WO-2023173016-A1 KRAS INHIBITORS FOR TREATING DISEASE BLOSSOMHILL THERAPEUTICS, INC. (US) 2023-09-14 WO disclosed
WO-2023173017-A1 KRAS INHIBITORS FOR TREATING DISEASE BLOSSOMHILL THERAPEUTICS, INC. (US) 2023-09-14 WO disclosed
WO-2002036599-A1 THIENO[2,3-C]ISOQUINOLINES FOR USE AS INHIBITORS OF PARP SMITHKLINE BEECHAM P.L.C. (GB) 2002-05-10 WO disclosed
WO-2002000626-A1 FUSED AZEPINE DERIVATIVES AND THEIR USE AS ANTIDIURETIC AGENTS FERRING B.V. (NL) 2002-01-03 WO disclosed
EP-1098650-A1 BENZOQUINOLIZIDINE AND BENZOINDOLIZIDINE DERIVATIVES AND THERAPEUTIC USES THEREOF AMERICAN BIOGENETIC SCIENCES, INC. (US) 2001-05-16 EP disclosed
US-6183934-B1 FOE USE IN FORMATION OF PATTERN OF INSULATION FILM, PASSIVATION FILM, .ALPHA.-RAY SHIELDING FILM, OPTICAL WAVEGUIDE KABUSHIKI KAISHA TOSHIBA (JP) 2001-02-06 US disclosed
EP-1019409-A1 POLY(ADP-RIBOSE) POLYMERASE (\"PARP\") INHIBITORS, METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING NEURAL OR CARDIOVASCULAR TISSUE DAMAGE GUILFORD PHARMACEUTICALS INC. (US) 2000-07-19 EP disclosed
WO-2000004905-A1 BENZOQUINOLIZIDINE AND BENZOINDOLIZIDINE DERIVATIVES AND THERAPEUTIC USES THEREOF AMERICAN BIOGENETIC SCIENCES, INC. (US) 2000-02-03 WO disclosed
WO-1999011645-A1 POLY(ADP-RIBOSE) POLYMERASE ('PARP') INHIBITORS, METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING NEURAL OR CARDIOVASCULAR TISSUE DAMAGE GUILFORD PHARMACEUTICALS INC. (US) 1999-03-11 WO disclosed
EP-0457243-A1 Novel tricyclic compounds SYNTEX (U.S.A.) INC. (US) 1991-11-21 EP disclosed