Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 10/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.33 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29911790 | 0.79 | TRPA1 (0.59) | TRPA1CYP1A2MAOAMAOBCYP2A6 | |
| SCHEMBL642263 | 0.79 | TRPA1 (0.59) | TRPA1CYP1A2MAOAMAOBCYP2A6 | |
| Hydrochloric Acid SCHEMBL11023474 | 0.78 | TRPA1 (0.57) | TRPA1CYP1A2MAOAMAOBCYP2A6 | |
| SCHEMBL555661 | 0.68 | ALOX15 (0.39) | MAOAMAOBBCHECES1 | |
| SCHEMBL6127702 | 0.68 | CYP1A2 (0.38) | TRPA1CYP1A2MAOAMAOBCYP2A6 | |
| SCHEMBL6274084 | 0.68 | CYP1A2 (0.38) | TRPA1CYP1A2MAOAMAOBCYP2A6 | |
| SCHEMBL6997599 | 0.68 | TRPA1 (0.46) | TRPA1MAOAMAOBCYP11B1CYP11B2 | |
| SCHEMBL7500741 | 0.67 | MAOA (0.44) | TRPA1MAOAMAOB | |
| SCHEMBL2940889 | 0.67 | TRPA1 (0.44) | TRPA1CYP1A2MAOAMAOBIP6K1 | |
| SCHEMBL14361835 | 0.67 | TRPA1 (0.53) | TRPA1CYP1A2MAOAMAOBCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10093624-B2 | NAMPT and ROCK inhibitors | ABBVIE INC. (US) | 2018-10-09 | — | — | US | claimed |
| US-9302989-B2 | NAMPT and rock inhibitors | ABBVIE INC. (US) | 2016-04-05 | — | — | US | claimed |
| US-20120122842-A1 | NAMPT AND ROCK INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | claimed |
| US-10093624-B2 | NAMPT and ROCK inhibitors | ABBVIE INC. (US) | 2018-10-09 | — | — | US | disclosed |
| EP-2776393-B1 | NAMPT INHIBITORS | ABBVIE INC (US) | 2017-12-20 | — | — | EP | disclosed |
| US-9758511-B2 | NAMPT inhibitors | ABBVIE INC. (US) | 2017-09-12 | — | — | US | disclosed |
| US-20170253562-A1 | Nampt Inhibitors | ABBVIE INC (US) | 2017-09-07 | — | — | US | disclosed |
| US-20170135994-A9 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2017-05-18 | — | — | US | disclosed |
| US-20170065575-A1 | NAMPT INHIBITORS | ABBVIE INC (US) | 2017-03-09 | — | — | US | disclosed |
| US-20160193209-A1 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2016-07-07 | — | — | US | disclosed |
| US-20160184281-A1 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2016-06-30 | — | — | US | disclosed |
| WO-2013170113-A1 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2013-11-14 | — | — | WO | disclosed |
| WO-2013170118-A1 | THIAZOLECARBOXAMIDE DERIVATIVES FOR USE AS NAMPT INHIBITORS | ABBVIE INC. (US) | 2013-11-14 | — | — | WO | disclosed |
| EP-2640698-A1 | NAMPT AND ROCK INHIBITORS | AbbVie Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| EP-2640704-A1 | NAMPT INHIBITORS | Abbvie Inc. (US) | 2013-09-25 | — | — | EP | disclosed |
| WO-2013067710-A1 | NAMPT INHIBITORS | ABBOTT LABORATORIES (US) | 2013-05-16 | — | — | WO | disclosed |
| WO-2012067965-A1 | NAMPT AND ROCK INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-24 | — | — | WO | disclosed |
| WO-2012067963-A1 | NAMPT INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-24 | — | — | WO | disclosed |
| US-20120122924-A1 | NAMPT INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | disclosed |
| US-20120122842-A1 | NAMPT AND ROCK INHIBITORS | ABBOTT LABORATORIES (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122924-A1 | NAMPT INHIBITORS | NAMPT, NNMT, NAPRT | TRPA1 4538/4885CYP1A2 4236/4885MAOA 497/4885 |
| US-10093624-B2 | NAMPT and ROCK inhibitors | NAMPT, NNMT, NADK | TRPA1 3664/4885CYP1A2 3392/4885MAOA 592/4885 |
| US-20120122842-A1 | NAMPT AND ROCK INHIBITORS | NAMPT, NNMT, NME2 | TRPA1 4631/4885CYP1A2 4188/4885MAOA 280/4885 |
| US-20170253562-A1 | Nampt Inhibitors | NAMPT, NNMT, NAPRT | TRPA1 4538/4885CYP1A2 4236/4885MAOA 497/4885 |
| US-20170065575-A1 | NAMPT INHIBITORS | NAMPT, NNMT, NAPRT | TRPA1 4538/4885CYP1A2 4236/4885MAOA 497/4885 |
| US-20160184281-A1 | NAMPT INHIBITORS | NAMPT, NNMT, NAPRT | TRPA1 4538/4885CYP1A2 4236/4885MAOA 497/4885 |
| US-20170135994-A9 | NAMPT INHIBITORS | NAMPT, NNMT, NAPRT | TRPA1 4538/4885CYP1A2 4236/4885MAOA 497/4885 |
| US-20160193209-A1 | NAMPT INHIBITORS | NAMPT, NNMT, NAPRT | TRPA1 4538/4885CYP1A2 4236/4885MAOA 497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.