Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HTR6 | P50406 | 5/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | KRAS | P01116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6038551 | 0.90 | HTR2C (0.56) | HDAC1HDAC6HTR6HTR2AHTR2C | |
| SCHEMBL4300297 | 0.82 | HDAC1 (0.53) | HDAC1HDAC6HTR6HTR2AHTR2C | |
| SCHEMBL9615137 | 0.81 | HTR2A (0.55) | HDAC1HDAC6HTR6HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL9696491 | 0.80 | KDM4E (0.56) | HDAC1HDAC6HTR6HTR2AHTR2C | |
| SCHEMBL9903966 | 0.80 | CA1 (0.65) | HDAC1HDAC6HTR6HTR2AHTR2C | |
| SCHEMBL6422248 | 0.79 | HDAC1 (0.69) | HDAC1HDAC6HTR6HTR2AHTR2C | |
| SCHEMBL6422112 | 0.78 | HTR2C (0.55) | HDAC1HDAC6HTR6HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL9615118 | 0.78 | HDAC1 (0.67) | HDAC1HDAC6HTR6HTR2AHTR2C | |
| SCHEMBL12369406 | 0.76 | HDAC1 (0.53) | HDAC1HDAC6HTR6HTR2AHTR2C | |
| SCHEMBL9615110 | 0.76 | NPC1 (0.54) | HDAC1HDAC6HTR6HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057814-B1 | TETRAHYDROBENZINDOLE DERIVATIVES | MEIJI SEIKA KAISHA (JP) | 2005-03-09 | — | — | EP | disclosed |
| US-6498251-B1 | Tetrahydrobenzindole derivatives | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-1057814-A1 | TETRAHYDROBENZINDOLE DERIVATIVES | Meiji Seika Kaisha, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |