SCHEMBL6423017

SCHEMBL6423017

COc1ccc([N+](=O)[O-])c(C2=Cc3ccc(OCc4ccccc4)cc3CC2)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 6/20 0.43
CYP11B1 P15538 2/20 0.42
CYP11B2 P19099 2/20 0.42
CYP19A1 P11511 1/20 0.41
MAOA P21397 5/20 0.41
PTGS2 P35354 1/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
MAPT P10636 1/20 0.41
HRH3 Q9Y5N1 1/20 0.40
BACE1 P56817 1/20 0.39
AR P10275 1/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
ATM Q13315 1/20 0.39
MMP1 P03956 1/20 0.39
MMP2 P08253 1/20 0.39
MMP7 P09237 1/20 0.39
MMP9 P14780 1/20 0.39
MMP12 P39900 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL227550 0.92 MAOB (0.43) MAOBCYP11B1CYP11B2CYP19A1MAOA
SCHEMBL31187239 0.92 MAOB (0.43) MAOBCYP11B1CYP11B2CYP19A1MAOA
SCHEMBL225788 0.89 MEN1 (0.44) MAOBMAOAPTGS2MEN1KMT2A
SCHEMBL6421445 0.87 MAOB (0.49) MAOBMAOAMEN1KMT2AMAPT
SCHEMBL225762 0.83 CYP11B1 (0.51) MAOBCYP11B1CYP11B2CYP19A1PTGS2
SCHEMBL15876168 0.83 PTGS2 (0.47) MAOBCYP11B1CYP11B2CYP19A1PTGS2
SCHEMBL227692 0.83 MAOB (0.48) MAOBMAOAMEN1KMT2AAR
SCHEMBL6422074 0.80 CYP11B1 (0.48) MAOBCYP11B1CYP11B2CYP19A1MAOA
SCHEMBL226071 0.79 CYP11B1 (0.53) CYP11B1CYP11B2CYP19A1PTGS2MAPT
SCHEMBL22346026 0.77 MAPT (0.44) MAOBCYP11B1CYP11B2CYP19A1MAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1577288-A1 SELECTIVE ESTROGEN RECEPTOR MODULATORS Eisai Co., Ltd. (JP) 2005-09-21 EP disclosed