Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 8/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.54 |
| ▸ | RET | P07949 | 2/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 8/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2115533 | 0.92 | PDGFRB (0.62) | PDGFRBFGFR1RETALKABL1 | |
| SCHEMBL2115532 | 0.92 | PDGFRB (0.62) | PDGFRBFGFR1RETALKABL1 | |
| SCHEMBL29016217 | 0.85 | LMNA (0.46) | PDGFRBFGFR1RETALKABL1 | |
| SCHEMBL3804361 | 0.81 | KDR (0.59) | PDGFRBFGFR1RETALKABL1 | |
| SCHEMBL3720975 | 0.81 | KDR (0.59) | PDGFRBFGFR1RETALKABL1 | |
| SCHEMBL5392303 | 0.80 | PDGFRB (0.74) | PDGFRBFGFR1RETALKABL1 | |
| SCHEMBL6391494 | 0.79 | FGFR1 (0.72) | PDGFRBFGFR1RETALKABL1 | |
| SCHEMBL6391497 | 0.79 | FGFR1 (0.72) | PDGFRBFGFR1RETALKABL1 | |
| SCHEMBL23064738 | 0.78 | ALDH1A1 (0.43) | PDGFRBFGFR1RETALKABL1 | |
| SCHEMBL23064739 | 0.78 | ALDH1A1 (0.43) | PDGFRBFGFR1RETALKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427326-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CANCER | SUGEN INC (US) | 2005-06-08 | — | — | EP | disclosed |
| EP-1427326-A2 | COMBINATION THERAPY FOR THE TREATMENT OF CANCER | Sugen, Inc. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003015608-A2 | COMBINATION THERAPY FOR THE TREATMENT OF CANCER | SUGEN, INC. (US) | 2003-02-27 | — | — | WO | disclosed |