Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.81 |
| ▸ | ITGAV | P06756 | 20/20 | 0.81 |
| ▸ | ITGB5 | P18084 | 11/20 | 0.63 |
| ▸ | ITGB6 | P18564 | 11/20 | 0.63 |
| ▸ | ITGB8 | P26012 | 11/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7995002 | 0.93 | ITGB3 (0.82) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL6420861 | 0.90 | ITGB3 (1.00) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL6420863 | 0.90 | ITGB3 (1.00) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL6422671 | 0.90 | ITGB3 (1.00) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL6105718 | 0.89 | ITGB3 (0.63) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL6421100 | 0.89 | ITGB3 (1.00) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL6105960 | 0.88 | ITGB3 (0.62) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL6421320 | 0.86 | ITGB3 (0.67) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL6421324 | 0.86 | ITGB3 (0.67) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| Trifluoroacetic Acid SCHEMBL6422001 | 0.85 | ITGAV (0.91) | ITGB3ITGAVITGB5ITGB6ITGB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1040098-B1 | INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2005-04-27 | — | — | EP | disclosed |
| US-6784190-B2 | USEFUL FOR INHIBITING BONE RESORPTION, TREATING AND PREVENTING OSTEOPOROSIS, VASCULAR RESTENOSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, ANGIOGENESIS, TUMOR, ATHEROSCLEROSIS, INFLAMMATION, WOUND HEALING, VIRAL DISEASEDISEASE, TUMOR | MERCK & CO., INC. | 2004-08-31 | — | — | US | disclosed |
| US-6297249-B1 | SUBSTITUTED 2-CARBOXYALKYLPYRIDINES | MERCK & CO., INC. | 2001-10-02 | — | — | US | disclosed |
| US-6048861-A | OSTEOPOROSIS; BONE DISORDERS; CARDIOVASCULAR DISORDERS; ANTIINFLAMMATROY AGENTS; WOUND HEALING AGENTS | MERCK & CO., INC. (US) | 2000-04-11 | — | — | US | disclosed |