Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14850693 | 0.92 | TSHR (0.41) | TSHRCTSSCTSKCTSLCTSB | |
| SCHEMBL16435346 | 0.86 | CTSS (0.45) | TSHRCTSSCTSKCTSLCTSB | |
| SCHEMBL3500871 | 0.86 | USP2 (0.44) | TSHRCYP2C19CTSSCTSKCTSL | |
| SCHEMBL3492474 | 0.86 | USP2 (0.44) | TSHRCYP2C19CTSSCTSKCTSL | |
| SCHEMBL14850788 | 0.83 | ITGB3 (0.45) | TSHRCTSSCTSKCTSLCTSB | |
| SCHEMBL14497033 | 0.81 | SYK (0.60) | CTSKALDH1A1ITGB3ITGA2BTGM2 | |
| SCHEMBL14850864 | 0.81 | ITGB3 (0.46) | TSHRCTSSCTSKCTSLCTSB | |
| SCHEMBL14850855 | 0.80 | ITGB3 (0.47) | TSHRCTSSCTSKCTSLCTSB | |
| SCHEMBL14850692 | 0.80 | ITGB3 (0.47) | TSHRCTSSCTSKCTSLCTSB | |
| SCHEMBL16435373 | 0.80 | HRH2 (0.47) | TSHRSIGMAR1CTSSCTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1577302-A1 | NOVEL ETHYLENEDIAMINE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2005-09-21 | — | — | EP | disclosed |