Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.43 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.43 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP12 | P39900 | 2/20 | 0.42 |
| ▸ | MMP13 | P45452 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6423606 | 1.00 | KDM4E (0.53) | KDM4EHTTAKR1C3LDHAPTPN7 | |
| SCHEMBL6423609 | 0.85 | ESR1 (0.46) | KDM4EHTTAKR1C3LDHAPDE4A | |
| SCHEMBL4658405 | 0.85 | LDHA (0.64) | HTTLDHAMMEMMP1KMT2A | |
| SCHEMBL4659113 | 0.84 | AKR1C3 (0.68) | KDM4EHTTAKR1C3AKR1C2KMT2A | |
| SCHEMBL4659114 | 0.84 | AKR1C3 (0.68) | KDM4EHTTAKR1C3AKR1C2KMT2A | |
| SCHEMBL5314275 | 0.75 | KDM4E (0.80) | KDM4EHTTAKR1C3AKR1C2KMT2A | |
| SCHEMBL5314277 | 0.75 | KDM4E (0.80) | KDM4EHTTAKR1C3AKR1C2KMT2A | |
| SCHEMBL28659073 | 0.74 | AKR1C3 (0.68) | KDM4EHTTAKR1C3AKR1C2KMT2A | |
| SCHEMBL3047079 | 0.74 | AKR1C3 (0.72) | KDM4EHTTAKR1C3AKR1C2KMT2A | |
| SCHEMBL30159708 | 0.74 | AKR1C3 (0.68) | KDM4EHTTAKR1C3AKR1C2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1251738-A4 | NOVEL DIPHENYLETHYLENE COMPOUNDS | CALYX THERAPEUTICS INC (US) | 2005-08-10 | — | — | EP | disclosed |
| EP-1251738-A1 | NOVEL DIPHENYLETHYLENE COMPOUNDS | Calyx Therapeutics, Inc. (US) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001056382-A1 | NOVEL DIPHENYLETHYLENE COMPOUNDS | CALYX THERAPEUTICS, INC. (US) | 2001-08-09 | — | — | WO | disclosed |