Sugi Predict

Sugi Predict / Compounds / SCHEMBL6423617

SCHEMBL6423617

SCHEMBL6423617

Cc1ccc(P(=O)(Cl)c2ccc(C)cc2C)c(C)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 2/20 0.39
▸ TP53 P04637 1/20 0.39
▸ ALDH1A1 P00352 2/20 0.35
▸ HTT P42858 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ MEN1 O00255 2/20 0.35
▸ KMT2A Q03164 2/20 0.35
▸ CYP1A2 P05177 2/20 0.35
▸ CYP2A6 P11509 2/20 0.35
▸ HPGD P15428 2/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ TAS1R3 Q7RTX0 1/20 0.34
▸ TAS1R1 Q7RTX1 1/20 0.34
▸ TAS1R2 Q8TE23 1/20 0.34
▸ GAA P10253 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ TSHR P16473 1/20 0.33
▸ RAPGEF4 Q8WZA2 1/20 0.33
▸ FLT1 P17948 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9001006 0.86 TDP1 (0.39) TDP1TP53ALDH1A1HTTSMN1; SMN2
SCHEMBL1204500 0.81 TDP1 (0.42) TDP1TP53ALDH1A1MEN1KMT2A
SCHEMBL563887 0.77 CYP1A2 (0.51) TDP1TP53ALDH1A1HTTSMN1; SMN2
SCHEMBL497565 0.77 LMNA (0.48) TDP1TP53ALDH1A1HTTSMN1; SMN2
SCHEMBL30155025 0.77 CYP1A2 (0.51) TDP1TP53ALDH1A1HTTSMN1; SMN2
Hydrochloric Acid SCHEMBL10914729 0.76 CYP1A2 (0.50) TDP1TP53ALDH1A1HTTSMN1; SMN2
SCHEMBL1726472 0.74 TP53 (0.37) TDP1TP53SMN1; SMN2MEN1KMT2A
SCHEMBL13910328 0.72 HPGD (0.38) TDP1TP53ALDH1A1HTTMEN1
SCHEMBL10779964 0.71 TDP1 (0.42) TDP1TP53ALDH1A1SMN1; SMN2MEN1
SCHEMBL1186561 0.71 TSHR (0.43) TDP1ALDH1A1CYP1A2CYP2A6HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1131378-B1 FLAME RETARDANT RESIN COMPOSITIONS CONTAINING PHOSPHORAMIDES, AND METHOD FOR MAKING GEN ELECTRIC (US) 2005-02-23 — — EP disclosed
US-6569929-B2 Containing thermoplastic resins GENERAL ELECTRIC COMPANY 2003-05-27 — — US disclosed
US-20020019466-A1 Method to prepare phosphoramides, and resin compositions containing them SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2002-02-14 — — US disclosed
EP-1131378-A1 FLAME RETARDANT RESIN COMPOSITIONS CONTAINING PHOSPHORAMIDES, AND METHOD FOR MAKING GENERAL ELECTRIC COMPANY (US) 2001-09-12 — — EP disclosed
WO-2000012612-A1 FLAME RETARDANT RESIN COMPOSITIONS CONTAINING PHOSPHORAMIDES, AND METHOD FOR MAKING GENERAL ELECTRIC COMPANY (US) 2000-03-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020019466-A1 Method to prepare phosphoramides, and resin compositions containing them PPA1, PHOSPHO1, PFAS TDP1 1331/4885TP53 1950/4885ALDH1A1 2919/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.