Bromide

Bromide

SCHEMBL6423749

Br.CC(CCN(C)C)N(C)C

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 10/20 0.38
CHRNA4 P43681 10/20 0.38
CHRNB4 P30926 8/20 0.38
CHRNA3 P32297 6/20 0.37
HTR2A P28223 1/20 0.36
HRH1 P35367 1/20 0.36
ALDH1A1 P00352 1/20 0.33
TSHR P16473 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
CA12 O43570 1/20 0.33
CA2 P00918 1/20 0.33
CA3 P07451 1/20 0.33
CA4 P22748 1/20 0.33
CA6 P23280 1/20 0.33
CA5A P35218 1/20 0.33
CA7 P43166 1/20 0.33
CA9 Q16790 1/20 0.33
CA14 Q9ULX7 1/20 0.33
CA5B Q9Y2D0 1/20 0.33
DNM1 Q05193 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL175509 0.97 CHRNB2 (0.39) CHRNB2CHRNA4CHRNB4CHRNA3HTR2A
SCHEMBL20860599 0.97 CHRNB2 (0.39) CHRNB2CHRNA4CHRNB4CHRNA3HTR2A
Hydrochloric Acid SCHEMBL3127060 0.94 CHRNB2 (0.38) CHRNB2CHRNA4CHRNB4CHRNA3HTR2A
SCHEMBL9311457 0.87 ALDH1A1 (0.55) CHRNB2CHRNA4CHRNB4CHRNA3HTR2A
Dimethylaminoethanol SCHEMBL9646794 0.85 MAPT (0.57) CHRNB2CHRNA4CHRNB4CHRNA3HTR2A
SCHEMBL10426599 0.85 CHRNB2 (0.33) CHRNB2CHRNA4CHRNB4CHRNA3HTR2A
SCHEMBL11236052 0.81 MAPT (0.46) CHRNB2CHRNA4CHRNB4CHRNA3CA12
SCHEMBL10868726 0.81 CHRNB2 (0.39) CHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL2564603 0.80 CHRNB2 (0.46) CHRNB2CHRNA4CHRNB4CHRNA3HTR2A
SCHEMBL13315455 0.80 CHRNB2 (0.35) CHRNB2CHRNA4CHRNB4CHRNA3HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2005145924-A QUATERNARY AMMONIUM SALT KOEI CHEM CO LTD 2005-06-09 JP disclosed