Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 5/20 | 0.44 |
| ▸ | PRKCA | P17252 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6425680 | 0.85 | GSK3B (0.49) | KDRGSK3BPRKCA | |
| SCHEMBL6425117 | 0.83 | CCNE2 (0.52) | KDRGSK3BPRKCA | |
| SCHEMBL6424169 | 0.80 | PRKCA (0.40) | GSK3BPRKCA | |
| SCHEMBL6425702 | 0.79 | CCNE2 (0.54) | — | |
| Hydrochloric Acid SCHEMBL6424165 | 0.79 | PRKCA (0.40) | GSK3BPRKCA | |
| SCHEMBL7496358 | 0.78 | GSK3B (0.60) | KDRGSK3BPRKCA | |
| SCHEMBL27503774 | 0.76 | GSK3B (0.37) | GSK3BPRKCA | |
| Enmd-981693 SCHEMBL29350364 | 0.76 | CCNE2 (0.69) | GSK3B | |
| Enmd-981693 SCHEMBL608128 | 0.76 | CCNE2 (0.69) | GSK3B | |
| SCHEMBL668748 | 0.73 | CCNE2 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1229374-C | Substituted bisindolylmaleimides for inhibition of cell proliferation | HOFFMANN LA ROCHE (CH) | 2005-11-30 | — | — | CN | claimed |
| EP-1242408-B1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | HOFFMANN LA ROCHE (CH) | 2005-10-12 | — | — | EP | claimed |
| CN-1409709-A | Substituted bisindolylmaleimides for inhibition of cell proliferation | HOFFMANN LA ROCHE (CH) | 2003-04-09 | — | — | CN | claimed |
| EP-1242408-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | claimed |
| US-6313143-B1 | USEFUL IN THERAPY OF CELL PROLIFERATIVE DISORDERS SUCH AS CANCER | HOFFMANN-LA ROCHE INC. | 2001-11-06 | — | — | US | claimed |
| WO-2001044234-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-21 | — | — | WO | claimed |
| CN-1229374-C | Substituted bisindolylmaleimides for inhibition of cell proliferation | HOFFMANN LA ROCHE (CH) | 2005-11-30 | — | — | CN | disclosed |
| EP-1242408-B1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | HOFFMANN LA ROCHE (CH) | 2005-10-12 | — | — | EP | disclosed |
| CN-1409709-A | Substituted bisindolylmaleimides for inhibition of cell proliferation | HOFFMANN LA ROCHE (CH) | 2003-04-09 | — | — | CN | disclosed |
| EP-1242408-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| US-6313143-B1 | USEFUL IN THERAPY OF CELL PROLIFERATIVE DISORDERS SUCH AS CANCER | HOFFMANN-LA ROCHE INC. | 2001-11-06 | — | — | US | disclosed |
| WO-2001044234-A1 | SUBSTITUTED BISINDOLYLMALEIMIDES FOR THE INHIBITION OF CELL PROLIFERATION | F. HOFFMANN-LA ROCHE AG (CH) | 2001-06-21 | — | — | WO | disclosed |