Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5992884 | 0.92 | — | — | |
| Bromide SCHEMBL3853944 | 0.77 | CNR2 (0.42) | MAPTCYP2C9CYP2C19 | |
| Bromide SCHEMBL6423648 | 0.71 | MAPT (0.36) | GAAMAPTCYP2C9CYP2C19SMN1; SMN2 | |
| Bromide SCHEMBL3844964 | 0.70 | L3MBTL1 (0.43) | — | |
| Bromide SCHEMBL3848580 | 0.70 | L3MBTL1 (0.43) | — | |
| Bromide SCHEMBL3854345 | 0.70 | L3MBTL1 (0.43) | — | |
| Bromide SCHEMBL7050342 | 0.70 | NPC1 (0.32) | SMN1; SMN2 | |
| Bromide SCHEMBL3846477 | 0.68 | ALDH1A1 (0.55) | GAAMAPTSMN1; SMN2 | |
| Bromide SCHEMBL5980166 | 0.68 | ALDH1A1 (0.30) | MAPT | |
| Bromide SCHEMBL5979587 | 0.67 | MAPT (0.35) | GAAMAPTCYP2C9CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1353669-A4 | METHOD FOR TREATING GLAUCOMA IB | ALTEON INC (US) | 2005-10-19 | — | — | EP | disclosed |
| EP-1353669-A1 | METHOD FOR TREATING GLAUCOMA IB | Alteon, Inc. (US) | 2003-10-22 | — | — | EP | disclosed |
| WO-2002053158-A1 | METHOD FOR TREATING GLAUCOMA IB | ALTEON, INC. (US) | 2002-07-11 | — | — | WO | disclosed |