Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | ALDH3A1 | P30838 | 3/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 5/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | FLT4 | P35916 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GMNN | O75496 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylpiperazine SCHEMBL6424762 | 1.00 | KDR (0.55) | KDRALDH1A1ALDH3A1CA1CA2 | |
| SCHEMBL4575601 | 0.95 | KDR (0.60) | KDRALDH1A1ALDH3A1CA1CA2 | |
| SCHEMBL4575597 | 0.95 | KDR (0.60) | KDRALDH1A1ALDH3A1CA1CA2 | |
| SCHEMBL4575494 | 0.87 | KDR (0.63) | KDRALDH1A1ALDH3A1CA1CA2 | |
| SCHEMBL4575487 | 0.87 | KDR (0.63) | KDRALDH1A1ALDH3A1CA1CA2 | |
| SCHEMBL5472939 | 0.86 | KDR (0.61) | KDRALDH1A1ALDH3A1CA1CA2 | |
| SCHEMBL5472944 | 0.86 | KDR (0.61) | KDRALDH1A1ALDH3A1CA1CA2 | |
| SCHEMBL5750362 | 0.79 | KDR (0.58) | KDRALDH1A1ALDH3A1CA1CA2 | |
| SCHEMBL5750356 | 0.79 | KDR (0.58) | KDRALDH1A1ALDH3A1CA1CA2 | |
| SCHEMBL5820102 | 0.78 | ALDH3A1 (0.58) | ALDH1A1ALDH3A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427326-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CANCER | SUGEN INC (US) | 2005-06-08 | — | — | EP | disclosed |
| EP-1427326-A2 | COMBINATION THERAPY FOR THE TREATMENT OF CANCER | Sugen, Inc. (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003015608-A2 | COMBINATION THERAPY FOR THE TREATMENT OF CANCER | SUGEN, INC. (US) | 2003-02-27 | — | — | WO | disclosed |