Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | ALDH3A1 | P30838 | 4/20 | 0.57 |
| ▸ | CA1 | P00915 | 3/20 | 0.57 |
| ▸ | CA2 | P00918 | 3/20 | 0.57 |
| ▸ | RET | P07949 | 5/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | FLT1 | P17948 | 2/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | FLT4 | P35916 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4575597 | 1.00 | KDR (0.60) | KDRALDH1A1ALDH3A1CA1CA2 | |
| Methylpiperazine SCHEMBL6424765 | 0.95 | KDR (0.55) | KDRALDH1A1ALDH3A1CA1CA2 | |
| Methylpiperazine SCHEMBL6424762 | 0.95 | KDR (0.55) | KDRALDH1A1ALDH3A1CA1CA2 | |
| SCHEMBL4575494 | 0.91 | KDR (0.63) | KDRALDH1A1ALDH3A1CA1CA2 | |
| SCHEMBL4575487 | 0.91 | KDR (0.63) | KDRALDH1A1ALDH3A1CA1CA2 | |
| SCHEMBL5472939 | 0.90 | KDR (0.61) | KDRALDH1A1ALDH3A1CA1CA2 | |
| SCHEMBL5472944 | 0.90 | KDR (0.61) | KDRALDH1A1ALDH3A1CA1CA2 | |
| SCHEMBL5750362 | 0.83 | KDR (0.58) | KDRALDH1A1ALDH3A1CA1CA2 | |
| SCHEMBL5750356 | 0.83 | KDR (0.58) | KDRALDH1A1ALDH3A1CA1CA2 | |
| SCHEMBL5820102 | 0.82 | ALDH3A1 (0.58) | ALDH1A1ALDH3A1CA1CA2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | claimed |
| EP-1696906-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | Leo Pharma A/S (DK) | 2006-09-06 | — | — | EP | claimed |
| WO-2005058309-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | LEO PHARMA A/S (DK) | 2005-06-30 | — | — | WO | claimed |
| US-7320996-B2 | Indolinone protein kinase inhibitors and cyclooxygenase inhibitors for use in combination therapy for the treatment of cancer | SUGEN, INC (US) | 2008-01-22 | — | — | US | disclosed |
| US-20070167488-A1 | Novel therapeutic use | LEO PHARMA A/S (DK) | 2007-07-19 | — | — | US | disclosed |
| EP-1453502-A4 | PHARMACEUTICAL FORMULATIONS COMPRISING INDOLINONE DERIVATIVES | SUGEN INC (US) | 2007-01-10 | — | — | EP | disclosed |
| US-7112603-B2 | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives | AGOURON PHARMACEUTICALS, INC. (US) | 2006-09-26 | — | — | US | disclosed |
| US-7109185-B2 | Pharmaceutical formulations comprising indolinone derivatives | SUGEN, INC. (US) | 2006-09-19 | — | — | US | disclosed |
| EP-1696906-A1 | NOVEL THERAPEUTIC USE OF INDOLINONE DERIVATIVES | Leo Pharma A/S (DK) | 2006-09-06 | — | — | EP | disclosed |
| EP-1301507-B1 | MANNICH BASE PRODRUGS OF 3 - (PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AND THEIR USE AS MODULATORS OF PROTEIN KINASES | SUGEN INC (US) | 2006-07-19 | — | — | EP | disclosed |
| US-7053113-B2 | Mannich base prodrugs of 3-(pyrrol-2-yl-methylidene)-2-indolinone derivatives | SUGEN, INC. (US) | 2006-05-30 | — | — | US | disclosed |
| EP-1301507-A2 | MANNICH BASE PRODRUGS OF 3 - (PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AND THEIR USE AS MODULATORS OF PROTEIN KINASES | Sugen, Inc. (US) | 2003-04-16 | — | — | EP | disclosed |
| WO-2003015608-A2 | COMBINATION THERAPY FOR THE TREATMENT OF CANCER | SUGEN, INC. (US) | 2003-02-27 | — | — | WO | disclosed |
| EP-1283835-A2 | 3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS | Sugen, Inc. (US) | 2003-02-19 | — | — | EP | disclosed |
| US-6482848-B2 | KINASE INHIBITORS | SUGEN INCORPORATED | 2002-11-19 | — | — | US | disclosed |
| US-20020037878-A1 | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives | PHARMACIA & UPJOHN COMPANY | 2002-03-28 | — | — | US | disclosed |
| US-20020032204-A1 | Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives | SUGEN INCORPORATED | 2002-03-14 | — | — | US | disclosed |
| WO-2001090103-A9 | 3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS | SUGEN INC (US) | 2002-03-07 | — | — | WO | disclosed |
| WO-2001090103-A2 | 3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS | SUGEN, INC. (US) | 2001-11-29 | — | — | WO | disclosed |
| WO-2001090068-A2 | MANNICH BASE PRODRUGS OF 3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AND THEIR USE A MODULATORS OF PROTEIN KINASES | SUGEN, INC. (US) | 2001-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020037878-A1 | Prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives | DMPK, PNKP, PHKG2 | KDR 1123/4885ALDH1A1 2136/4885ALDH3A1 1188/4885 |
| US-20020032204-A1 | Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives | DMPK, PNKP, PLK2 | KDR 3028/4885ALDH1A1 2147/4885ALDH3A1 1292/4885 |
| US-20070167488-A1 | Novel therapeutic use | MAG, PMP22, MYT1 | KDR 4334/4885ALDH1A1 2943/4885ALDH3A1 2869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.