⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14698860 | 0.89 | NPC1 (0.41) | — | |
| SCHEMBL12181006 | 0.79 | FABP4 (0.30) | — | |
| SCHEMBL31543251 | 0.79 | GCK (0.34) | — | |
| SCHEMBL23214263 | 0.75 | — | — | |
| SCHEMBL16024975 | 0.73 | — | — | |
| SCHEMBL1080305 | 0.73 | — | — | |
| SCHEMBL20711404 | 0.69 | HCRTR1 (0.36) | — | |
| SCHEMBL23964565 | 0.69 | POLB (0.35) | — | |
| SCHEMBL20202179 | 0.66 | CHRNB2 (0.41) | — | |
| SCHEMBL20320417 | 0.65 | PDE10A (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12545682-B2 | Heterocyclic derivatives as P2X7 receptor antagonists | BREYE THERAPEUTICS APS (DK) | 2026-02-10 | — | — | US | disclosed |
| EP-4262975-B1 | HETEROCYCLIC DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | BREYE THERAPEUTICS APS (DK) | 2025-03-05 | — | — | EP | disclosed |
| CN-111712492-B | Cyclotriazoles as LPA antagonists | 百时美施贵宝公司 | 2024-05-31 | — | — | CN | disclosed |
| US-20240034737-A1 | Heterocyclic Derivatives as P2X7 Receptor Antagonists | BREYE THERAPEUTICS APS (DK) | 2024-02-01 | — | — | US | disclosed |
| CN-117157291-A | Heterocyclic derivatives as P2X7 receptor antagonists | 布雷耶疗法有限公司 | 2023-12-01 | — | — | CN | disclosed |
| EP-4262975-A1 | HETEROCYCLIC DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | Breye Therapeutics ApS (DK) | 2023-10-25 | — | — | EP | disclosed |
| WO-2023084449-A1 | DIAMINOCYCLOPENTYLPYRIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE OR DISORDER | NOVARTIS AG (CH) | 2023-05-19 | — | — | WO | disclosed |
| EP-3728224-B1 | CYCLOHEXYL ACID TRIAZOLE AZOLES AS LPA ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2023-01-11 | — | — | EP | disclosed |
| WO-2022129365-A1 | HETEROCYCLIC DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | AXXAM S.P.A. (IT) | 2022-06-23 | — | — | WO | disclosed |
| EP-4015039-A1 | HETEROCYCLIC DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS | AXXAM S.p.A. (IT) | 2022-06-22 | — | — | EP | disclosed |
| WO-2013189841-A1 | NEW BICYCLIC THIOPHENYLAMIDE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-12-27 | — | — | WO | disclosed |
| WO-2013024168-A1 | PIPERAZINE THIAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF TAUOPATHIES SUCH AS ALZHEIMER'S DISEASE | REMYND NV (BE) | 2013-02-21 | — | — | WO | disclosed |
| US-20100285957-A1 | THIAZOLYLOXYPHENYLAMIDINES OR THIADIAZOLYLOXYPHENYLAMIDINES AND THEIR USE AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2010-11-11 | — | — | US | disclosed |
| WO-2005007636-A1 | 1,2,4- THIADIAZOL-5-THIO COMPOUNDS AND THE DERIVATIVES THEREOF, METHODS FOR THE PRODUCTION THEREOF AND USE THEREOF AS UREASE AND NITRIFICATION INHIBITORS | SKW STICKSTOFFWERKE PIESTERITZ GMBH (DE) | 2005-01-27 | — | — | WO | disclosed |
| CN-1143962-A | Triazole compound and processes for preparation thereof | YUHAN CORP (KR) | 1997-02-26 | — | — | CN | disclosed |
| EP-0751943-A1 | TRIAZOLE COMPOUNDS AND PROCESSES FOR THE PREPARATION THEREOF | Yuhan Corporation (KR) | 1997-01-08 | — | — | EP | disclosed |
| WO-1995025107-A1 | TRIAZOLE COMPOUNDS AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORPORATION (KR) | 1995-09-21 | — | — | WO | disclosed |
| US-5405853-A | Potent muscarinic agonists having good central nervous system penetrability | MERCK SHARPE & DOHME LTD. (GB) | 1995-04-11 | — | — | US | disclosed |
| EP-0307142-B1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME (GB) | 1994-09-14 | — | — | EP | disclosed |
| EP-0307142-A1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | disclosed |