Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.51 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.49 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.49 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.49 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.49 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.49 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.49 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.49 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.49 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.49 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.49 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.49 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.49 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.49 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.49 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28015030 | 0.84 | NAMPT (0.46) | FAAH | |
| SCHEMBL5538152 | 0.82 | STS (0.50) | PRMT5WDR77CACNB4CACNA1ACACNA1G | |
| SCHEMBL27390505 | 0.82 | GPR119 (0.46) | MAPTPRMT5WDR77GPR119KDM4E | |
| SCHEMBL26636928 | 0.82 | PRMT5 (0.45) | PRMT5WDR77GPR119KDM4EPKM | |
| SCHEMBL30735309 | 0.82 | PRMT5 (0.45) | PRMT5WDR77GPR119KDM4EPKM | |
| SCHEMBL30824916 | 0.82 | GPR119 (0.46) | MAPTPRMT5WDR77GPR119KDM4E | |
| SCHEMBL31071544 | 0.80 | KEAP1 (0.52) | MAPTKEAP1NFE2L2PRMT5WDR77 | |
| SCHEMBL3172041 | 0.79 | MAPT (0.57) | MAPTKEAP1NFE2L2STSGPR119 | |
| SCHEMBL391051 | 0.78 | GPR119 (0.56) | KEAP1NFE2L2PRMT5WDR77GPR119 | |
| SCHEMBL31303428 | 0.78 | STS (0.52) | KEAP1NFE2L2PRMT5WDR77STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2570418-A2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-20 | — | — | EP | disclosed |
| EP-1555267-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES | OTSUKA PHARMA CO LTD (JP) | 2013-01-16 | — | — | EP | disclosed |
| EP-1555267-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-07-20 | — | — | EP | disclosed |