SCHEMBL6425411

SCHEMBL6425411

CNCC(c1ccccc1)c1ccc2c(c1)[C@@]13CCN4CC5=CCO[C@H]6CC(=O)N2[C@H]1[C@H]6[C@H]5C[C@H]43

nearest known ligand 0.69

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GLRA1 P23415 15/20 0.69
GLRB P48167 15/20 0.69
CYP3A4 P08684 2/20 0.69
MEN1 O00255 2/20 0.69
KMT2A Q03164 2/20 0.69
TAS2R10 Q9NYW0 2/20 0.69
SCN1A P35498 1/20 0.69
TAS2R46 P59540 1/20 0.69
SCN2A Q99250 1/20 0.69
SCN3A Q9NY46 1/20 0.69
CHRM1 P11229 1/20 0.62
SMN1; SMN2 Q16637 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Strychnine SCHEMBL21985190 0.82 GLRA1 (1.00) GLRA1GLRBCYP3A4MEN1KMT2A
Strychnine SCHEMBL14117483 0.82 GLRA1 (1.00) GLRA1GLRBCYP3A4MEN1KMT2A
Strychnine SCHEMBL14029424 0.82 GLRA1 (1.00) GLRA1GLRBCYP3A4MEN1KMT2A
Strychnine SCHEMBL14047653 0.82 GLRA1 (1.00) GLRA1GLRBCYP3A4MEN1KMT2A
Strychnine SCHEMBL12549549 0.82 GLRA1 (1.00) GLRA1GLRBCYP3A4MEN1KMT2A
SCHEMBL24177883 0.81 GLRA1 (1.00) GLRA1GLRBCYP3A4MEN1KMT2A
Strychnine SCHEMBL15475787 0.81 GLRA1 (0.95) GLRA1GLRBCYP3A4MEN1KMT2A
SCHEMBL4654859 0.81 GLRA1 (1.00) GLRA1GLRBCYP3A4MEN1KMT2A
Strychnine SCHEMBL184168 0.81 GLRA1 (0.98) GLRA1GLRBCYP3A4MEN1KMT2A
Strychnine SCHEMBL25300604 0.81 GLRA1 (0.98) GLRA1GLRBCYP3A4MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3452464-A1 PYRAZOLE DERIVATIVES, COMPOSITIONS AND THERAPEUTIC USE THEREOF H. Hoffnabb-La Roche Ag (CH) 2019-03-13 EP disclosed
EP-3380474-A1 JANUS KINASES INHIBITORS, COMPOSITIONS THEREOF AND USE THEREOF H. Hoffnabb-La Roche Ag (CH) 2018-10-03 EP disclosed
EP-3262035-A1 ALKYNYL ALCOHOLS AND METHODS OF USE F. Hoffmann-La Roche AG (CH) 2018-01-03 EP disclosed
WO-2017191098-A1 PYRAZOLE DERIVATIVES, COMPOSITIONS AND THERAPEUTIC USE THEREOF F. HOFFMANN-LA ROCHE AG (CH) 2017-11-09 WO disclosed
WO-2017089390-A1 JANUS KINASES INHIBITORS, COMPOSITIONS THEREOF AND USE THEREOF F. HOFFMANN-LA ROCHE AG (CH) 2017-06-01 WO disclosed
EP-3145929-A1 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS F. Hoffmann-La Roche AG (CH) 2017-03-29 EP disclosed
EP-3077384-A1 HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS WITH ELECTROPHILIC FUNCTIONALITY F. Hoffmann-La Roche AG (CH) 2016-10-12 EP disclosed
WO-2016135163-A1 ALKYNYL ALCOHOLS AND METHODS OF USE F. HOFFMANN-LA ROCHE AG (CH) 2016-09-01 WO disclosed
EP-3036230-A1 ALKYNYL ALCOHOLS AND METHODS OF USE F. Hoffmann-La Roche AG (CH) 2016-06-29 EP disclosed
EP-3036229-A1 ALKYNYL ALCOHOLS AND METHODS OF USE F. Hoffmann-La Roche AG (CH) 2016-06-29 EP disclosed
WO-2016001341-A1 SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE F. HOFFMANN-LA ROCHE AG (CH) 2016-01-07 WO disclosed
WO-2015177326-A1 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2015-11-26 WO disclosed
EP-2900657-A1 CYCLIC ETHER PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE F. Hoffmann-La Roche AG (CH) 2015-08-05 EP disclosed
WO-2015082583-A1 HETEROARYL PYRIDONE AND AZA-PYRIDONE COMPOUNDS WITH ELECTROPHILIC FUNCTIONALITY F. HOFFMANN-LA ROCHE AG (CH) 2015-06-11 WO disclosed
WO-2015025026-A1 ALKYNYL ALCOHOLS AND METHODS OF USE F. HOFFMANN-LA ROCHE AG (CH) 2015-02-26 WO disclosed
WO-2015025025-A1 ALKYNYL ALCOHOLS AND METHODS OF USE F. HOFFMANN-LA ROCHE AG (CH) 2015-02-26 WO disclosed
EP-1509537-A2 CELLULAR ACCUMULATION OF PHOSPHONATE ANALOGS OF HIV PROTEASE INHIBITOR COMPOUNDS AND THE COMPOUNDS AS SUCH GILEAD SCIENCES, INC. (US) 2005-03-02 EP disclosed
WO-2003090690-A2 CELLULAR ACCUMULATION OF PHOSPHONATE ANALOGS OF HIV PROTEASE INHIBITOR COMPOUNDS AND THE COMPOUNDS AS SUCH GILEAD SCIENCES, INC. (US) 2003-11-06 WO disclosed