Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 7/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL642615 | 1.00 | KDM4C (0.40) | KDM4CTAS1R3TAS1R1TAS1R2KMT2A | |
| Hydrochloric Acid SCHEMBL642292 | 0.82 | HTR6 (0.35) | KDM4CTAS1R3TAS1R1TAS1R2HTR6 | |
| Phosphoric Acid SCHEMBL642612 | 0.81 | KDM4C (0.44) | KDM4CHTR6 | |
| SCHEMBL10126117 | 0.78 | HTR6 (0.46) | KDM4CTAS1R3TAS1R1TAS1R2HTR6 | |
| SCHEMBL642613 | 0.78 | KDM4C (0.36) | KDM4CTAS1R3TAS1R1TAS1R2KMT2A | |
| Hydrochloric Acid SCHEMBL642203 | 0.78 | KDM4C (0.47) | KDM4CTAS1R3TAS1R1TAS1R2KMT2A | |
| SCHEMBL645874 | 0.77 | KDM4C (0.43) | KDM4CTAS1R3TAS1R1TAS1R2KMT2A | |
| SCHEMBL10110864 | 0.76 | KDM4C (0.43) | KDM4CHTR6 | |
| SCHEMBL13288488 | 0.73 | HTR6 (0.46) | KDM4CHTR6 | |
| SCHEMBL643298 | 0.73 | HTR6 (0.66) | KDM4CHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119842-B2 | Process for synthesis of amino-methyl tetralin derivatives | Roche Palo Alto LLP (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2379491-A1 | PROCESS FOR SYNTHESIS OF AMINO-METHYL TETRALINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010069778-A1 | PROCESS FOR SYNTHESIS OF AMINO-METHYL TETRALINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-06-24 | — | — | WO | disclosed |