Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | IL1B | P01584 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6427572 | 0.93 | RECQL (0.48) | RECQLAURKAAURKBKDM4ESMN1; SMN2 | |
| SCHEMBL6428652 | 0.86 | SMN1; SMN2 (0.44) | ROCK2ROCK1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL6426372 | 0.85 | TSHR (0.47) | AURKAAURKBKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL5032372 | 0.84 | KDM4E (0.42) | AURKAAURKBKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL6426371 | 0.84 | RAB9A (0.42) | SMN1; SMN2NPC1RAB9APOLBALDH1A1 | |
| SCHEMBL6428744 | 0.84 | HPGD (0.45) | RECQLAURKAAURKBKDM4ESMN1; SMN2 | |
| SCHEMBL5027586 | 0.83 | AURKA (0.40) | AURKAAURKBKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL6428670 | 0.83 | AURKA (0.46) | AURKAKDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL6428558 | 0.83 | DRD2 (0.39) | SMN1; SMN2HPGDALDH1A1MAPT | |
| SCHEMBL6426323 | 0.83 | ABL1 (0.37) | SMN1; SMN2HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050261339-A1 | Pyrazole compound and medicinal composition containing the same | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261339-A1 | Pyrazole compound and medicinal composition containing the same | CNKSR1, NR3C2, CSNK2B | BRD4 305/4885RECQL 4114/4885IL1B 686/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.